Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | ornithine decarboxylase, putative | 0.0122 | 0.3743 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0105 | 0.2914 | 0.7793 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0122 | 0.3743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.2914 | 0.2213 |
Leishmania major | p450 reductase, putative | 0.0105 | 0.2914 | 0.4194 |
Loa Loa (eye worm) | pyridoxal-dependent decarboxylase | 0.0122 | 0.3743 | 0.3124 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0105 | 0.2914 | 0.5 |
Toxoplasma gondii | diaminopimelate decarboxylase | 0.0122 | 0.3743 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0065 | 0.09 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0105 | 0.2914 | 0.4194 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0247 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0105 | 0.2914 | 0.4194 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0122 | 0.3743 | 1 |
Schistosoma mansoni | lipoxygenase | 0.012 | 0.3665 | 1 |
Trypanosoma brucei | ornithine decarboxylase | 0.0122 | 0.3743 | 1 |
Mycobacterium tuberculosis | Diaminopimelate decarboxylase LysA (DAP decarboxylase) | 0.0122 | 0.3743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0105 | 0.2914 | 0.7283 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0093 | 0.2315 | 0.6186 |
Brugia malayi | FAD binding domain containing protein | 0.0105 | 0.2914 | 0.2213 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0105 | 0.2914 | 0.7786 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0122 | 0.3743 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0247 | 1 | 1 |
Leishmania major | ornithine decarboxylase, putative | 0.0122 | 0.3743 | 1 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0122 | 0.3743 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0105 | 0.2914 | 0.7283 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0122 | 0.3743 | 1 |
Mycobacterium leprae | PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE) | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.012 | 0.3665 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0084 | 0.1855 | 0.4681 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0105 | 0.2914 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0105 | 0.2914 | 0.7283 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0065 | 0.09 | 0.1876 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0122 | 0.3743 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0105 | 0.2914 | 0.2213 |
Giardia lamblia | Ornithine decarboxylase | 0.0122 | 0.3743 | 1 |
Trichomonas vaginalis | pyridoxal-dependent decarboxylase, putative | 0.0122 | 0.3743 | 1 |
Brugia malayi | Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein | 0.0122 | 0.3743 | 0.3124 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0053 | 0.0301 | 0.0118 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.012 | 0.3665 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0105 | 0.2914 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0105 | 0.2914 | 0.5 |
Mycobacterium ulcerans | diaminopimelate decarboxylase LysA | 0.0122 | 0.3743 | 1 |
Onchocerca volvulus | 0.0122 | 0.3743 | 0.5 | |
Brugia malayi | flavodoxin family protein | 0.0105 | 0.2914 | 0.2213 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0105 | 0.2914 | 0.7283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.