Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Binding activity (binding) | = 3000 | Evaluated for its binding affinity towards cytosol receptor in human myeloid leukemia cells (HL-60), by using 1alpha,25-(OH)2D3 as radioligand | ChEMBL. | 2993611 |
Phagocytosis (functional) | = 120 | Evaluated for its ability to induce phagocytosis in human myeloid leukemia cells (HL-60) | ChEMBL. | 2993611 |
Phagocytosis (functional) | = 130 | Evaluated for its ability to induce phagocytosis in human myeloid leukemia cells (HL-60) | ChEMBL. | 2993611 |
T/C (functional) | = 1.61 | In vitro bone-reabsorbing activity was examined in fetal mouse calvaria prelabeled with 45 Ca at 12 nM concentration, Ca release | ChEMBL. | 2993612 |
T/C (functional) | = 2.43 | In vitro bone-reabsorbing activity was examined in fetal mouse calvaria prelabeled with 45 Ca at 120 nM concentration, Ca release | ChEMBL. | 2993612 |
T/C (functional) | = 1.61 | In vitro bone-reabsorbing activity was examined in fetal mouse calvaria prelabeled with 45 Ca at 12 nM concentration, Ca release | ChEMBL. | 2993612 |
T/C (functional) | = 2.43 | In vitro bone-reabsorbing activity was examined in fetal mouse calvaria prelabeled with 45 Ca at 120 nM concentration, Ca release | ChEMBL. | 2993612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.