Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Rattus norvegicus | Acyl-CoA desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | fatty acid desaturase, putative | 0.0223 | 1 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0205 | 0.8673 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0223 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0205 | 0.8673 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0087 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0087 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0205 | 0.8673 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0087 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.019 | 0.7607 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0087 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0087 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.019 | 0.7607 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0087 | 0 | 0.5 |
Onchocerca volvulus | 0.0223 | 1 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0087 | 0 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0205 | 0.8673 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0223 | 1 | 0.5 |
Onchocerca volvulus | 0.0223 | 1 | 0.5 | |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0177 | 0.6621 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 85 nM | Inhibition of rat SCD1 in rat liver microsome | ChEMBL. | 21871798 |
IC50 (binding) | = 268 nM | Inhibition of SCD1 in human HepG2 cells | ChEMBL. | 21871798 |
Inhibition (binding) | Inhibition of delta-5 desaturase | ChEMBL. | 21871798 | |
Inhibition (binding) | Inhibition of delta-6 desaturase | ChEMBL. | 21871798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.