Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0283 | 0 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0283 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0283 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0283 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0283 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0283 | 0 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0283 | 0 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0283 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0283 | 0 | 0.5 |
Onchocerca volvulus | 0.0283 | 0 | 0.5 | |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.1295 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0283 | 0 | 0.5 |
Brugia malayi | Lipase family protein | 0.0283 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.