Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0316 | 0.1031 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.1315 | 0.995 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0316 | 0.1031 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.017 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0418 | 0.3067 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0418 | 0.3067 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0418 | 0.3067 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0316 | 0.1031 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.017 | 0.0554 |
Trypanosoma brucei | lipase domain protein, putative | 0.0418 | 0.3067 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0418 | 0.3067 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0316 | 0.1031 |
Brugia malayi | Lipase family protein | 0.0418 | 0.3067 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0418 | 0.3067 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0418 | 0.3067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.017 | 0.0554 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0418 | 0.3067 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0418 | 0.3067 | 0.5 |
Onchocerca volvulus | 0.0418 | 0.3067 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0418 | 0.3067 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.