Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase D2 | Starlite/ChEMBL | No references |
Homo sapiens | phospholipase D1, phosphatidylcholine-specific | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | phosphatidylglycerophosphate synthase, putative | 0.002 | 0.0022 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.126 | 0.9948 | 1 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0043 | 0.021 | 0.0592 |
Echinococcus multilocularis | phospholipase D1 | 0.0124 | 0.0857 | 0.2568 |
Echinococcus multilocularis | phospholipase D | 0.011 | 0.0741 | 0.2199 |
Echinococcus granulosus | phospholipase D1 | 0.0124 | 0.0857 | 0.2568 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 0.0857 | 1 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0043 | 0.021 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0511 | 0.1541 |
Plasmodium falciparum | mitochondrial cardiolipin synthase, putative | 0.002 | 0.0022 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0416 | 0.3192 | 1 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.002 | 0.0022 | 0.5 |
Brugia malayi | Lipase family protein | 0.0416 | 0.3192 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.0124 | 0.0857 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0416 | 0.3192 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cardiolipin synthase | 0.002 | 0.0022 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0416 | 0.3192 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0416 | 0.3192 | 1 |
Plasmodium falciparum | phosphatidylglycerophosphate synthase | 0.002 | 0.0022 | 0.5 |
Onchocerca volvulus | 0.0416 | 0.3192 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0698 | 0.2133 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0023 | 0.0051 | 0.009 |
Trypanosoma brucei | lipase domain protein, putative | 0.0416 | 0.3192 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0051 | 0.009 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0416 | 0.3192 | 1 |
Chlamydia trachomatis | phospholipase D superfamily protein | 0.002 | 0.0022 | 0.5 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.002 | 0.0022 | 0.5 |
Echinococcus granulosus | phospholipase D | 0.011 | 0.0741 | 0.2199 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0511 | 0.1541 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0023 | 0.0051 | 0.009 |
Schistosoma mansoni | phospholipase D | 0.0124 | 0.0857 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0416 | 0.3192 | 1 |
Plasmodium vivax | cardiolipin synthetase, putative | 0.002 | 0.0022 | 0.5 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.002 | 0.0022 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0698 | 0.2133 |
Chlamydia trachomatis | phospholipase D superfamily protein | 0.002 | 0.0022 | 0.5 |
Loa Loa (eye worm) | phospholipase D | 0.0023 | 0.0051 | 0.009 |
Chlamydia trachomatis | phospholipase D endonuclease family protein | 0.002 | 0.0022 | 0.5 |
Trypanosoma brucei | cardiolipin synthetase | 0.0043 | 0.021 | 0.0592 |
Leishmania major | hypothetical protein, conserved | 0.0416 | 0.3192 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0416 | 0.3192 | 1 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0043 | 0.021 | 0.0592 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0416 | 0.3192 | 0.5 |
Brugia malayi | Phospholipase d protein 1 | 0.0124 | 0.0857 | 0.2635 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0.17 uM | PUBCHEM_BIOASSAY: PLD2 purified enzyme concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
IC50 (functional) | 0.55 uM | PUBCHEM_BIOASSAY: Cellular PLD2 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
IC50 (functional) | 1.085 uM | PUBCHEM_BIOASSAY: PLD1 purified enzyme concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
IC50 (functional) | 5.9 uM | PUBCHEM_BIOASSAY: Cellular PLD1 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.