Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nicotinamide phosphoribosyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Loa Loa (eye worm) | pre-B cell enhancing factor | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Schistosoma japonicum | ko:K03462 nicotinamide phosphoribosyltransferase [EC2.4.2.12], putative | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Schistosoma japonicum | ko:K03462 nicotinamide phosphoribosyltransferase [EC2.4.2.12], putative | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Brugia malayi | Pre-B cell enhancing factor precursor | Get druggable targets OG5_133520 | All targets in OG5_133520 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adhesion regulating molecule 1 | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Echinococcus multilocularis | adhesion regulating molecule 1 | 0.052 | 1 | 1 |
Schistosoma mansoni | adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) | 0.052 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0271 | 0 | 0.5 |
Onchocerca volvulus | Proteasomal ubiquitin receptor ADRM1 homolog | 0.033 | 0.238 | 0.5 |
Toxoplasma gondii | adhesion regulating molecule region protein, putative | 0.052 | 1 | 0.5 |
Plasmodium falciparum | 26S proteasome regulatory subunit RPN13, putative | 0.0271 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.0035 uM | Cytotoxicity against human HCT116 cells after 72 hrs | ChEMBL. | 21080724 |
IC50 (binding) | = 0.0014 uM | Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotide | ChEMBL. | 21080724 |
INH (binding) | = 0.00023 uM | Inhibition of Nampt activity in H2O2-induced DNA damage in human MCF10A cells stably transfected with PIK3CA (H1047R) assessed as loss of PARP activity | ChEMBL. | 21080724 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.