Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.326 | 0.326 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.326 | 0.326 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.5338 | 0.774 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.326 | 1 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0095 | 0.5176 | 0.5176 |
Giardia lamblia | Hypothetical protein | 0.0095 | 0.5176 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.326 | 0.326 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0098 | 0.5338 | 0.5338 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0095 | 0.5176 | 0.7505 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0095 | 0.5176 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2331 | 0.2331 |
Brugia malayi | Trypsin family protein | 0.0098 | 0.5338 | 0.774 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.326 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.326 | 1 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0095 | 0.5176 | 0.5176 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2331 | 0.2331 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2331 | 0.2331 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0095 | 0.5176 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2331 | 0.2331 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.326 | 1 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0095 | 0.5176 | 0.5 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0095 | 0.5176 | 0.5 |
Plasmodium vivax | protease, putative | 0.002 | 0.0668 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.2331 | 0.338 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.2331 | 0.338 |
Echinococcus multilocularis | geminin | 0.0175 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.326 | 0.326 |
Onchocerca volvulus | 0.0098 | 0.5338 | 1 | |
Treponema pallidum | hypothetical protein | 0.002 | 0.0668 | 0.5 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0095 | 0.5176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.5176 | 0.7505 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2331 | 0.2331 |
Plasmodium falciparum | protease, putative | 0.002 | 0.0668 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.6896 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2331 | 0.2331 |
Chlamydia trachomatis | hypothetical protein | 0.002 | 0.0668 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0095 | 0.5176 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.326 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2331 | 0.2331 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.5338 | 0.774 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0095 | 0.5176 | 0.5176 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0095 | 0.5176 | 0.5176 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0098 | 0.5338 | 0.5338 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.6896 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.6896 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Papp (ADMET) | = 32 10'-6 cm/s | Apparent permeability across human Caco-2 cells | ChEMBL. | 20541405 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.