Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0054 | 0.0054 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0956 | 0.1761 |
Echinococcus granulosus | aurora kinase A | 0.0065 | 0.1238 | 0.2281 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0153 | 0.3874 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0054 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 1 | 1 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0065 | 0.1238 | 0.1238 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0153 | 0.3874 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0956 | 0.0956 |
Trichomonas vaginalis | AGC family protein kinase | 0.0065 | 0.1238 | 0.3195 |
Loa Loa (eye worm) | AUR protein kinase | 0.0065 | 0.1238 | 0.1238 |
Trypanosoma brucei | aurora B kinase | 0.0065 | 0.1238 | 1 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0153 | 0.3874 | 0.7139 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0956 | 0.1761 |
Echinococcus multilocularis | aurora kinase A | 0.0065 | 0.1238 | 0.2281 |
Echinococcus granulosus | geminin | 0.0205 | 0.5426 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0153 | 0.3874 | 1 |
Giardia lamblia | Aurora kinase | 0.0065 | 0.1238 | 0.3195 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0065 | 0.1238 | 0.2281 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0956 | 0.1761 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0054 | 0.0139 |
Trichomonas vaginalis | AGC family protein kinase | 0.0065 | 0.1238 | 0.3195 |
Loa Loa (eye worm) | AUR protein kinase | 0.0065 | 0.1238 | 0.1238 |
Loa Loa (eye worm) | AUR protein kinase | 0.0065 | 0.1238 | 0.1238 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0956 | 0.1761 |
Entamoeba histolytica | protein kinase, putative | 0.0065 | 0.1238 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5426 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0065 | 0.1238 | 0.3195 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0054 | 0.0054 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0054 | 0.0139 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0054 | 0.0139 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0065 | 0.1238 | 0.1238 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0065 | 0.1238 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0956 | 0.1761 |
Entamoeba histolytica | protein kinase , putative | 0.0065 | 0.1238 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0054 | 0.0139 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0153 | 0.3874 | 0.7139 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0065 | 0.1238 | 1 |
Loa Loa (eye worm) | TTK protein kinase | 0.0153 | 0.3874 | 0.3874 |
Schistosoma mansoni | protein kinase | 0.0065 | 0.1238 | 0.2281 |
Brugia malayi | serine/threonine kinase 12 | 0.0065 | 0.1238 | 0.1238 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5426 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0065 | 0.1238 | 0.2281 |
Toxoplasma gondii | aurora kinase | 0.0065 | 0.1238 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0054 | 0.0139 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0153 | 0.3874 | 0.3874 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0065 | 0.1238 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0065 | 0.1238 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0956 | 0.1761 |
Echinococcus multilocularis | geminin | 0.0205 | 0.5426 | 1 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0153 | 0.3874 | 0.7139 |
Giardia lamblia | Kinase, TTK | 0.0153 | 0.3874 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0065 | 0.1238 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0956 | 0.0956 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0065 | 0.1238 | 0.2281 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0065 | 0.1238 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0065 | 0.1238 | 0.3195 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0065 | 0.1238 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0065 | 0.1238 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0054 | 0.0139 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0956 | 0.1761 |
Leishmania major | protein kinase, putative | 0.0065 | 0.1238 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.