TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 441.482 | Formula: C25H23N5O3
H donors: 5 H acceptors: 4 LogP: 3.15 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: NCCCCNC(=O)c1nc(c2c(c1)c1cc(O)ccc1[nH]2)C(=O)c1c[nH]c2c1cccc2
InChi: 1S/C25H23N5O3/c26-9-3-4-10-27-25(33)21-12-17-16-11-14(31)7-8-20(16)29-22(17)23(30-21)24(32)18-13-28-19-6-2-1-5-15(18)19/h1-2,5-8,11-13,28-29,31H,3-4,9-10,26H2,(H,27,33)
InChiKey: OEKNWQXJPPBNEO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0187	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0468	0.0437
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0187	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0165	0.2826	0.3622
Onchocerca volvulus		0.0038	0.0468	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0187	0.395
Onchocerca volvulus		0.0038	0.0468	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0468	0.0872
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0468	0.0437
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0468	0.0437
Echinococcus granulosus	serotonin receptor	0.0038	0.0468	0.0437
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.0424	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0468	0.0468
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0468	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0468	0.0872
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0468	0.0872
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0468	0.0437
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0165	0.2826	0.3622
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0375	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0468	0.0437
Brugia malayi	GnHR receptor homolog	0.0038	0.0468	0.0437
Trypanosoma brucei	glucose transporter, putative	0.0031	0.035	0.8107
Toxoplasma gondii	protein kinase, putative	0.0287	0.5089	1
Loa Loa (eye worm)	IRE protein kinase	0.0553	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0375	0.0444
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.0468	0.0437
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.035	0.0643
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0031	0.035	0.8107
Echinococcus granulosus	allatostatin A receptor	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0375	0.0375
Plasmodium falciparum	protein kinase 7	0.0287	0.5089	0.6557
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.1641	0.1614
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0375	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Brugia malayi	Serotonin receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0468	0.0437
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0375	0.0677
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0468	0.0437
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0468	0.0437
Onchocerca volvulus		0.0038	0.0468	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0331	0.0597
Echinococcus multilocularis	General substrate transporter	0.0087	0.1378	0.135
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0468	0.0872
Brugia malayi	hypothetical protein	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0468	0.0437
Leishmania major	glucose transporter, lmgt2	0.0031	0.035	0.8107
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0468	0.0437
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0468	0.0437
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0165	0.2826	0.5524
Schistosoma mansoni	protein kinase	0.0033	0.0375	0.0684
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0468	0.0437
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.003	0.0331	0.0299
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.1641	0.3261
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0187	0.02
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Trypanosoma brucei	glucose transporter 1E	0.0031	0.035	0.8107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0468	0.0872
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0468	0.0872
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.035	0.0643
Schistosoma mansoni	glucose transport protein	0.0101	0.1641	0.3217
Onchocerca volvulus		0.0038	0.0468	1
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.035	0.8107
Schistosoma mansoni	opsin-like receptor	0.0038	0.0468	0.0872
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0468	0.0437
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0468	0.0437
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0468	0.0437
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.1641	0.1614
Schistosoma mansoni	protein kinase	0.0033	0.0375	0.0684
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0468	0.0437
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0187	0.0155
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.0468	0.0437
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Plasmodium falciparum	protein kinase 6	0.0431	0.7745	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Trypanosoma brucei	glucose transporter, putative	0.0031	0.035	0.8107
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0468	0.0437
Leishmania major	glucose transporter, lmgt3	0.0031	0.035	0.8107
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Brugia malayi	G-protein coupled receptor	0.0038	0.0468	0.0437
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0468	0.0437
Brugia malayi	hypothetical protein	0.0038	0.0468	0.0437
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0468	0.0437
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Brugia malayi	sulfakinin receptor protein	0.0038	0.0468	0.0437
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0187	0.0306
Echinococcus multilocularis	serotonin receptor	0.0038	0.0468	0.0437
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.035	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0226	0.0226
Schistosoma mansoni	hypothetical protein	0.0038	0.0468	0.0872
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0375	0.0684
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.1641	0.1614
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0375	0.0343
Plasmodium vivax	proline--tRNA ligase, putative	0.0035	0.0424	0.0507
Schistosoma mansoni	opsin-like receptor	0.0038	0.0468	0.0872
Loa Loa (eye worm)	sugar transporter	0.0101	0.1641	0.1641
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0375	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0468	0.0468
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0331	0.0597
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.1641	0.1614
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0468	0.0437
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0375	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Schistosoma mansoni	opsin-like receptor	0.0038	0.0468	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.035	0.0643
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0468	0.0437
Onchocerca volvulus		0.0038	0.0468	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0468	0.0468
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0468	0.0437
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0468	0.0872
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0468	0.0872
Onchocerca volvulus		0.0038	0.0468	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0468	0.0437
Brugia malayi	hypothetical protein	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0468	0.0437
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0468	0.0872
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0468	0.0437
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0468	0.0437
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0033	0.5
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0375	0.0444
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0468	0.0872
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0468	0.0872
Echinococcus granulosus	sex peptide receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	General substrate transporter	0.0087	0.1378	0.135
Schistosoma mansoni	amine GPCR	0.0038	0.0468	0.0872
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.003	0.0331	0.0299
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0375	0.0343
Onchocerca volvulus		0.0038	0.0468	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0468	0.0437
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0375	0.0375
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0424	1
Onchocerca volvulus		0.0038	0.0468	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0468	0.0437
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0468	0.0468
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0468	0.0437
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0468	0.0872
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0375	0.0444
Brugia malayi	hypothetical protein	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0468	0.0437
Brugia malayi	hypothetical protein	0.0038	0.0468	0.0437
Schistosoma mansoni	hypothetical protein	0.0038	0.0468	0.0872
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0468	0.0872
Brugia malayi	hypothetical protein	0.0038	0.0468	0.0437
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0187	0.5182
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0468	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Brugia malayi	Sugar transporter family protein	0.0101	0.1641	0.1614
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0468	0.0437
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0087	0.1383
Entamoeba histolytica	protein kinase, putative	0.0033	0.0375	0.0191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Entamoeba histolytica	protein kinase, putative	0.0033	0.0375	0.0191
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0468	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0468	0.0437
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0468	0.0872
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0187	0.395
Schistosoma mansoni	amine GPCR	0.0038	0.0468	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0468	0.0872
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0468	0.0437
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0468	0.0437
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0033	0.0033
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0375	0.0343
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0375	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0468	0.0437
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0375	0.0444
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0468	0.0437
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0375	0.0343
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0468	0.0872
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0468	0.0872
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0124	1
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0375	0.0444
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.003	0.0331	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0038	0.0468	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0468	0.0437
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0468	0.0437
Loa Loa (eye worm)	sugar transporter	0.0014	0.0033	0.0033
Plasmodium falciparum	proline--tRNA ligase	0.0035	0.0424	0.0507
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0468	0.0437
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0187	0.3046
Onchocerca volvulus		0.0038	0.0468	1
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0375	0.8736
Trypanosoma brucei	glucose transporter, putative	0.0031	0.035	0.8107
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0187	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0468	0.0872
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0468	0.0437
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.035	0.0643
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0468	0.0468
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0468	0.0872
Trypanosoma brucei	glucose transporter, putative	0.0031	0.035	0.8107
Echinococcus granulosus	serine:threonine protein kinase:endoribonuclease	0.0553	1	1
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.035	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0375	0.0444
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0468	0.0437
Schistosoma mansoni	glucose transport protein	0.0101	0.1641	0.3217
Entamoeba histolytica	protein kinase, putative	0.0553	1	1
Echinococcus granulosus	hypothetical protein	0.0038	0.0468	0.0437
Brugia malayi	RE15519p	0.0038	0.0468	0.0437
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0375	0.0343
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0468	0.0468
Toxoplasma gondii	facilitative glucose transporter GT1	0.0101	0.1641	0.3181
Schistosoma mansoni	serine/threonine protein kinase	0.0284	0.5032	1
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0468	0.0437
Onchocerca volvulus		0.0038	0.0468	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0375	0.0693
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.0468	0.0437
Brugia malayi	Dopamine receptor protein 1	0.0038	0.0468	0.0437
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0136	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.003	0.0331	0.0299
Giardia lamblia	Prolyl-tRNA synthetase	0.003	0.0331	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0468	0.0872
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.003	0.0331	0.0605
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0101	0.1641	0.1614
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0375	0.0343
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0187	0.02
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0468	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0307	0.0275
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0468	0.0437
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.0468	0.0872
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0468	0.0468
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.035	0.8107
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0468	0.0437
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0187	0.5
Brugia malayi	neuropeptide F receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.1641	0.1614
Schistosoma mansoni	amine GPCR	0.0038	0.0468	0.0872
Loa Loa (eye worm)	hypothetical protein	0.003	0.0331	0.0331
Onchocerca volvulus		0.0038	0.0468	1
Echinococcus multilocularis	serotonin receptor	0.0038	0.0468	0.0437
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0375	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0424	1
Onchocerca volvulus		0.0038	0.0468	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Brugia malayi	putative neuropeptide receptor	0.0038	0.0468	0.0437
Trypanosoma brucei	glucose transporter, putative	0.0031	0.035	0.8107
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.1641	0.1614
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.035	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0468	0.0437
Trypanosoma brucei	glucose transporter, putative	0.0031	0.035	0.8107
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0468	0.0437
Schistosoma mansoni	hypothetical protein	0.0038	0.0468	0.0872
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Onchocerca volvulus		0.0038	0.0468	1
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0468	0.0437
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0187	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0468	0.0437
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0468	0.0437
Trypanosoma brucei	glucose transporter, putative	0.0031	0.035	0.8107
Echinococcus multilocularis	serine:threonine protein kinase:endoribonuclease	0.0553	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0468	0.0468
Brugia malayi	AKH receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0468	0.0437
Brugia malayi	larval opioid receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0468	0.0437
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.035	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0187	0.0187
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0468	0.0437
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0375	0.0677
Brugia malayi	Cam kinase protein 1	0.0033	0.0375	0.0343
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0468	0.0872
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0468	0.0437
Schistosoma mansoni	protein kinase	0.0033	0.0375	0.0684
Schistosoma mansoni	glucose transport protein	0.0101	0.1641	0.3217
Leishmania major	protein kinase, putative	0.0033	0.0375	0.8736
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0375	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Brugia malayi	hypothetical protein	0.0038	0.0468	0.0437
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0468	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Schistosoma mansoni	myosin xvIII	0.0038	0.0468	0.0872
Trypanosoma cruzi	hexose transporter	0.0031	0.035	0.8107
Trypanosoma brucei	glucose transporter, putative	0.0031	0.035	0.8107
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.003	0.0331	0.0146
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0038	0.0468	1
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.035	0.8107
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0468	0.0872
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0431	0.7745	1
Leishmania major	glucose transporter, lmgt1	0.0031	0.035	0.8107
Brugia malayi	G-protein coupled receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0468	0.0437
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0468	0.0437
Brugia malayi	hypothetical protein	0.0038	0.0468	0.0437
Schistosoma mansoni	adenoreceptor	0.0038	0.0468	0.0872
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.035	0.0643
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0307	0.0275
Trichomonas vaginalis	serine threonine-protein kinase, putative	0.0281	0.4964	1
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0468	0.0437
Onchocerca volvulus		0.0038	0.0468	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0187	0.395
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.1641	0.1614
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0124	1
Brugia malayi	G protein-coupled receptor	0.0038	0.0468	0.0437
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0468	0.0872
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0468	0.0437
Entamoeba histolytica	protein kinase, putative	0.0553	1	1
Brugia malayi	neuropeptide F receptor	0.0038	0.0468	0.0437
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0468	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0281	0.4964	1
Schistosoma mansoni	amine GPCR	0.0038	0.0468	0.0872
Brugia malayi	Dopamine receptor	0.0038	0.0468	0.0437
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0187	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Schistosoma mansoni	hypothetical protein	0.0101	0.1641	0.3217
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0468	0.0437
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0187	0.0155
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0035	0.0424	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0468	0.0872
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0468	0.0872
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0468	0.0437
Onchocerca volvulus		0.0038	0.0468	1
Echinococcus granulosus	somatostatin receptor	0.0038	0.0468	0.0437
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0187	0.0155
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0468	0.0468
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0468	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Brugia malayi	hypothetical protein	0.0038	0.0468	0.0437
Brugia malayi	Serotonin receptor	0.0038	0.0468	0.0437
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.0424	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0468	0.0468
Onchocerca volvulus		0.0038	0.0468	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0033	0.0033
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.003	0.0331	0.0299
Trypanosoma brucei	glucose transporter 2A	0.0031	0.035	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0375	0.0343
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.0468	0.0437
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0468	0.0872
Schistosoma mansoni	hypothetical protein	0.0038	0.0468	0.0872
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.035	0.8107
Plasmodium vivax	hexose transporter	0.0101	0.1641	0.2086
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0468	0.0872
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0468	0.0437
Loa Loa (eye worm)	hypothetical protein	0.003	0.0331	0.0331
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Schistosoma mansoni	amine GPCR	0.0038	0.0468	0.0872
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0468	0.0437
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0468	0.0437
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0468	0.0437
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0468	0.0872
Brugia malayi	hypothetical protein	0.0038	0.0468	0.0437
Plasmodium falciparum	hexose transporter	0.0101	0.1641	0.2086
Onchocerca volvulus		0.0038	0.0468	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0468	0.0872
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0468	0.0437
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0424	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0033	0.0033
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0468	0.0437
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0468	0.0468

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1910730

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1575851