Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.414 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.414 | 0.414 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.8486 | 0.8486 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0121 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0121 | 1 | 1 |
Trypanosoma brucei | Silent information regulator 2 related protein 3 | 0.0016 | 0 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0016 | 0 | 0.5 |
Plasmodium falciparum | transcriptional regulatory protein sir2a | 0.0016 | 0 | 0.5 |
Plasmodium vivax | NAD-dependent deacetylase, putative | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.414 | 1 |
Entamoeba histolytica | NAD-dependent deacetylase 1, putative | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0121 | 1 | 1 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0121 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.414 | 0.414 |
Plasmodium vivax | hypothetical protein, conserved | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0121 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.414 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.414 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.414 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0016 | 0 | 0.5 |
Plasmodium falciparum | transcriptional regulatory protein sir2b | 0.0016 | 0 | 0.5 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0016 | 0 | 0.5 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0121 | 1 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0016 | 0 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0121 | 1 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.414 | 0.414 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0121 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.414 | 1 |
Trypanosoma brucei | SIR2-like protein 4, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.414 | 0.414 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0016 | 0 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 3 | 0.0016 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.35 umol/ml | Inhibition of acrosin activity in human spermatozoa using N-alpha-benzoyl-DL-arginine para-nitroanilide-HCI as a substrate after 3 hrs by spectrophotometric analysis | ChEMBL. | 21983437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.