Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0124 | 1 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0124 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0124 | 1 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0124 | 1 | 0.5 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0124 | 1 | 0.5 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0124 | 1 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0124 | 1 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0124 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.8068 | 0.8068 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 20 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by agar diffusion method | ChEMBL. | 21879726 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.