Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Peripheral-type benzodiazepine receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Peripheral-type benzodiazepine receptor | 169 aa | 156 aa | 25.6 % | |
Echinococcus granulosus | vacuolar h atpase | Peripheral-type benzodiazepine receptor | 169 aa | 137 aa | 25.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0283 | 0.2743 | 0.8263 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.3319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.3319 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0283 | 0.2743 | 0.8263 |
Brugia malayi | brahma associated protein 60 kDa | 0.0283 | 0.2743 | 0.8263 |
Leishmania major | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0283 | 0.2743 | 0.8263 |
Plasmodium vivax | hypothetical protein, conserved | 0.0283 | 0.2743 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0101 | 0 | 0.5 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.0322 | 0.3319 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0283 | 0.2743 | 0.8263 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0101 | 0 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0283 | 0.2743 | 0.8263 |
Onchocerca volvulus | 0.0112 | 0.0171 | 0.0515 | |
Brugia malayi | TspO/MBR family protein | 0.0322 | 0.3319 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0101 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0283 | 0.2743 | 1 |
Mycobacterium ulcerans | tryptophan-rich sensory protein | 0.0322 | 0.3319 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0283 | 0.2743 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Onchocerca volvulus | 0.0322 | 0.3319 | 1 | |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0283 | 0.2743 | 0.2743 |
Leishmania major | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0283 | 0.2743 | 0.8263 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0101 | 0 | 0.5 |
Onchocerca volvulus | 0.0283 | 0.2743 | 0.8263 | |
Chlamydia trachomatis | SWIB complex protein | 0.0283 | 0.2743 | 0.5 |
Onchocerca volvulus | 0.0322 | 0.3319 | 1 | |
Echinococcus multilocularis | translocator protein | 0.0322 | 0.3319 | 0.3319 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0283 | 0.2743 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0283 | 0.2743 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0283 | 0.2743 | 0.8263 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0283 | 0.2743 | 0.2743 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0283 | 0.2743 | 0.2743 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.3319 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0767 | 1 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0112 | 0.0171 | 0.0515 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0101 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.013 | 0.0437 | 0.1317 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0283 | 0.2743 | 0.2743 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0283 | 0.2743 | 0.2743 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0283 | 0.2743 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0283 | 0.2743 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0283 | 0.2743 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0101 | 0 | 0.5 |
Onchocerca volvulus | 0.0322 | 0.3319 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0171 | 0.0515 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0283 | 0.2743 | 0.2743 |
Onchocerca volvulus | 0.0322 | 0.3319 | 1 | |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0101 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.3319 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0283 | 0.2743 | 0.8263 |
Echinococcus granulosus | translocator protein | 0.0322 | 0.3319 | 0.3319 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0101 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 65 nM | Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat brain homogenates after 90 mins by liquid scintillation spectrometry | ChEMBL. | 21916402 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.