Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cdc2-related kinase 1 | 0.0194 | 0.1907 | 0.8813 |
Echinococcus multilocularis | 0.0133 | 0.0611 | 0.0622 | |
Entamoeba histolytica | hypothetical protein | 0.0202 | 0.2068 | 0.908 |
Plasmodium falciparum | protein kinase 5 | 0.0194 | 0.1907 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0202 | 0.2068 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0194 | 0.1907 | 0.1939 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0194 | 0.1907 | 0.1939 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0138 | 0.0713 | 0.0725 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0194 | 0.1907 | 0.1939 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0548 | 0.9404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0569 | 0.9834 | 0.9834 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0194 | 0.1907 | 0.1907 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0194 | 0.1907 | 0.8813 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0194 | 0.1907 | 0.8813 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0138 | 0.0713 | 0.0725 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0194 | 0.1907 | 0.8813 |
Giardia lamblia | Kinase, CMGC CDK | 0.0194 | 0.1907 | 1 |
Echinococcus granulosus | dual specificity | 0.0202 | 0.2068 | 0.2102 |
Plasmodium vivax | protein kinase Crk2 | 0.0194 | 0.1907 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0194 | 0.1907 | 0.1939 |
Brugia malayi | hypothetical protein | 0.0272 | 0.3554 | 0.3779 |
Brugia malayi | Protein kinase domain containing protein | 0.0194 | 0.1907 | 0.2028 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0194 | 0.1907 | 0.8813 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0202 | 0.2068 | 0.908 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0194 | 0.1907 | 0.1939 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0138 | 0.0713 | 0.0725 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0202 | 0.2068 | 0.2068 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0202 | 0.2068 | 1 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0202 | 0.2068 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 activator 1 | 0.0569 | 0.9834 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1966 | 0.1966 |
Entamoeba histolytica | protein kinase, putative | 0.0202 | 0.2068 | 0.908 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1805 | 0.1805 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0122 | 0.037 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.3554 | 0.3554 |
Brugia malayi | cell division control protein 2 homolog | 0.0194 | 0.1907 | 0.2028 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0194 | 0.1907 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0202 | 0.2068 | 0.2199 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0202 | 0.2068 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1966 | 0.1966 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0138 | 0.0713 | 0.0713 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0212 | 0.2277 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0194 | 0.1907 | 0.8813 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0194 | 0.1907 | 1 |
Echinococcus multilocularis | dual specificity | 0.0202 | 0.2068 | 0.2102 |
Giardia lamblia | Kinase, CMGC CDK | 0.0194 | 0.1907 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0133 | 0.0611 | 0.0622 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0611 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.3554 | 0.3554 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0194 | 0.1907 | 0.1939 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0194 | 0.1907 | 0.8813 |
Brugia malayi | Protein kinase domain containing protein | 0.0138 | 0.0713 | 0.0758 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0194 | 0.1907 | 0.8813 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0194 | 0.1907 | 0.1907 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0194 | 0.1907 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0548 | 0.9404 | 0.9404 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0138 | 0.0713 | 0.0725 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0194 | 0.1907 | 0.8373 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0569 | 0.9834 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0202 | 0.2068 | 0.2102 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0194 | 0.1907 | 0.1939 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0194 | 0.1907 | 0.1907 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0569 | 0.9834 | 1 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0122 | 0.037 | 0.0377 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0194 | 0.1907 | 0.1939 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0194 | 0.1907 | 0.1939 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0194 | 0.1907 | 0.1939 |
Entamoeba histolytica | protein kinase, putative | 0.0202 | 0.2068 | 0.908 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0194 | 0.1907 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 18 uM | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay | ChEMBL. | 22196122 |
IC50 (functional) | = 23.4 uM | Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay | ChEMBL. | 22196122 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22196122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.