Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0604996 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.358059 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.358059 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0604996 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.358059 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.358059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.358059 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.358059 | 1 | 1 |
Onchocerca volvulus | 0.0604996 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.358059 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0604996 | 0 | 0.5 |
Onchocerca volvulus | 0.0604996 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.358059 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.221171 | 0.539966 | 0.539966 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0604996 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.358059 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.358059 | 1 | 1 |
Onchocerca volvulus | 0.0604996 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0604996 | 0 | 0.5 |
Onchocerca volvulus | 0.0604996 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0604996 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.358059 | 1 | 1 |
Onchocerca volvulus | 0.0604996 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.358059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.358059 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.200651 | 0.471004 | 0.471004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Bactericidal activity against Mycobacterium tuberculosis H37Rv in GASTD medium at 2 times MIC after 30 days by colony counting | ChEMBL. | 21940166 | |
IC50 (functional) | > 8 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium after 10 days by spectrophotometric analysis | ChEMBL. | 21940166 |
IC50 (functional) | > 8 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 after 10 days by spectrophotometric analysis | ChEMBL. | 21940166 |
MIC90 (functional) | > 8 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium after 10 days by spectrophotometric analysis | ChEMBL. | 21940166 |
MIC90 (functional) | > 8 uM | Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 after 10 days by spectrophotometric analysis | ChEMBL. | 21940166 |
Ratio (functional) | Ratio of MIC90 for Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 to MIC90 for Mycobacterium tuberculosis H37Rv in Fe-deficient GASTD medium | ChEMBL. | 21940166 | |
Ratio IC50 (functional) | Ratio of IC50 for Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 to IC50 for Mycobacterium tuberculosis H37Rv in Fe-deficient GASTD medium | ChEMBL. | 21940166 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mycobacterium tuberculosis | 21940166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.