Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0164 | 0.8583 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.8672 | 0.8573 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.008 | 0.3941 | 0.4545 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.3807 | 0.0993 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.8672 | 0.8573 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0164 | 0.8583 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0164 | 0.8583 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.8672 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.8672 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0037 | 0.1558 | 0.1796 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.3281 | 0.2779 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.3281 | 0.2779 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0037 | 0.1558 | 0.0928 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0164 | 0.8583 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0037 | 0.1558 | 0.1796 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.3281 | 0.2779 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.8672 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0037 | 0.1558 | 0.1796 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0037 | 0.1558 | 0.1796 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.3281 | 0.2779 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0037 | 0.1558 | 0.1796 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.008 | 0.3941 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0164 | 0.8583 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0164 | 0.8583 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0037 | 0.1558 | 0.0674 |
Brugia malayi | Cytochrome P450 family protein | 0.0015 | 0.032 | 0.0369 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0164 | 0.8583 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3281 | 0.3783 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.8672 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.3281 | 0.2779 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.008 | 0.3941 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.8672 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0164 | 0.8583 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.3281 | 0.2933 |
Echinococcus multilocularis | tumor protein p63 | 0.0189 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.8672 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.032 | 0.0369 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.3281 | 0.2779 |
Schistosoma mansoni | patched 1 | 0.0068 | 0.3281 | 0.2933 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0164 | 0.8583 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1044 | 0.1204 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0164 | 0.8583 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0164 | 0.8583 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.3281 | 0.2779 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.8672 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.3807 | 0.0993 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0164 | 0.8583 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0037 | 0.1558 | 0.0928 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.3807 | 0.0993 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.8672 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0037 | 0.1558 | 0.1796 |
Onchocerca volvulus | 0.0028 | 0.1044 | 0.5 | |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.3281 | 0.3783 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.3281 | 0.3783 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | = 29 nM | The compound was tested in vitro for inhibition of rat hepatic HMG-CoA reductase. | ChEMBL. | 1895299 |
IC50 (functional) | = 29 nM | The compound was tested in vitro for inhibition of rat hepatic HMG-CoA reductase. | ChEMBL. | 1895299 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.