Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.0478 | 0.4801 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0439 | 0.4375 | 0.4375 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0481 | 0.4832 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0478 | 0.4801 | 0.4801 |
Echinococcus granulosus | ectonucleoside triphosphate diphosphohydrolase | 0.0352 | 0.3416 | 0.3416 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0481 | 0.4832 | 1 |
Schistosoma mansoni | ATP-diphosphohydrolase 1 | 0.0352 | 0.3416 | 0.7115 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0238 | 0.2162 | 0.3423 |
Onchocerca volvulus | 0.0238 | 0.2162 | 0.5 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0481 | 0.4832 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0478 | 0.4801 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0478 | 0.4801 | 1 |
Schistosoma mansoni | adenylate kinase | 0.011 | 0.0749 | 0.156 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0439 | 0.4375 | 0.4375 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0352 | 0.3416 | 0.3416 |
Brugia malayi | dihydrofolate reductase family protein | 0.0478 | 0.4801 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0113 | 0.0789 | 1 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0352 | 0.3416 | 0.3416 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0478 | 0.4801 | 1 |
Plasmodium falciparum | apyrase, putative | 0.0352 | 0.3416 | 0.7069 |
Brugia malayi | Dihydrofolate reductase | 0.0478 | 0.4801 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0481 | 0.4832 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0481 | 0.4832 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0951 | 1 | 1 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0352 | 0.3416 | 0.3416 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0238 | 0.2162 | 0.4504 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0478 | 0.4801 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0439 | 0.4375 | 0.9113 |
Echinococcus granulosus | dihydrofolate reductase | 0.0478 | 0.4801 | 0.4801 |
Brugia malayi | thymidylate synthase | 0.0238 | 0.2162 | 0.3423 |
Echinococcus granulosus | thymidylate synthase | 0.0238 | 0.2162 | 0.2162 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0478 | 0.4801 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0238 | 0.2162 | 0.2162 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0481 | 0.4832 | 1 |
Treponema pallidum | adenylate kinase (adk) | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0113 | 0.0789 | 0.1633 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.