Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Aph-1 protein, putative | 0.0101 | 0.0696 | 1 |
Mycobacterium tuberculosis | Probable aminopeptidase PepC | 0.007 | 0.0418 | 0.5 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.026 | 0.2086 | 0.1741 |
Schistosoma mansoni | alpha-l-fucosidase | 0.1 | 0.8568 | 1 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.007 | 0.0418 | 0.0911 |
Mycobacterium leprae | PROBABLE AMINOPEPTIDASE PEPC | 0.007 | 0.0418 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0101 | 0.0696 | 1 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.1164 | 1 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.026 | 0.2086 | 0.1741 |
Leishmania major | aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 | 0.007 | 0.0418 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0225 | 0.1775 | 0.2072 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0418 | 0.0488 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.1 | 0.8568 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.1164 | 1 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0225 | 0.1775 | 0.2072 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.026 | 0.2086 | 0.2434 |
Plasmodium vivax | M18 aspartyl aminopeptidase, putative | 0.007 | 0.0418 | 0.5 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.007 | 0.0418 | 0.0911 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0439 | 0.3651 | 1 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.007 | 0.0418 | 0.0911 |
Entamoeba histolytica | aspartyl aminopeptidase, putative | 0.007 | 0.0418 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.026 | 0.2086 | 0.2434 |
Loa Loa (eye worm) | aspartyl aminopeptidase | 0.007 | 0.0418 | 0.0488 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0439 | 0.3651 | 1 |
Brugia malayi | Aspartyl aminopeptidase | 0.007 | 0.0418 | 0.0488 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0101 | 0.0696 | 1 |
Plasmodium falciparum | M18 aspartyl aminopeptidase | 0.007 | 0.0418 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0418 | 0.0488 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.026 | 0.2086 | 0.2046 |
Entamoeba histolytica | aminopeptidase, putative | 0.007 | 0.0418 | 0.5 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.1 | 0.8568 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 30 uM | Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay | ChEMBL. | 22209205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.