Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Chorion peroxidase homolog | 0.0143 | 0.8095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0338 | 0.0223 |
Onchocerca volvulus | 0.0143 | 0.8095 | 1 | |
Onchocerca volvulus | 0.0143 | 0.8095 | 1 | |
Brugia malayi | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.8095 | 0.8072 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.8095 | 0.8072 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0049 | 0.0335 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0166 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0143 | 0.8095 | 1 |
Onchocerca volvulus | 0.0143 | 0.8095 | 1 | |
Onchocerca volvulus | Peroxidase homolog | 0.0143 | 0.8095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0067 | 0.1865 | 0.1768 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0049 | 0.0335 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0067 | 0.1865 | 0.184 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0067 | 0.1865 | 0.1768 |
Echinococcus granulosus | peroxidasin | 0.0143 | 0.8095 | 0.8399 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0143 | 0.8095 | 0.8072 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0067 | 0.1865 | 0.1768 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.8095 | 0.8072 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0338 | 0.0223 |
Brugia malayi | jmjC domain containing protein | 0.0067 | 0.1865 | 0.1768 |
Brugia malayi | Peroxidasin | 0.0143 | 0.8095 | 0.8072 |
Schistosoma mansoni | peroxidasin | 0.0143 | 0.8095 | 0.8072 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0166 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0049 | 0.0335 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.8095 | 0.8072 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0067 | 0.1865 | 0.1768 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0338 | 0.0223 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.8095 | 0.8072 |
Onchocerca volvulus | Peroxidasin homolog | 0.0143 | 0.8095 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0067 | 0.1865 | 0.1768 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.8095 | 0.8072 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0045 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0338 | 0.0223 |
Brugia malayi | Blistered cuticle protein 3 | 0.0143 | 0.8095 | 0.8072 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0067 | 0.1865 | 0.184 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0067 | 0.1865 | 0.1768 |
Echinococcus multilocularis | peroxidasin | 0.0143 | 0.8095 | 0.8072 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0161 | 0.9616 | 1 |
Schistosoma mansoni | peroxidasin | 0.0143 | 0.8095 | 0.8072 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Loa Loa (eye worm) | acetyltransferase | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0143 | 0.8095 | 0.8072 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0049 | 0.0335 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Brugia malayi | jmjC domain containing protein | 0.0067 | 0.1865 | 0.1768 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.8095 | 0.8072 |
Brugia malayi | Animal haem peroxidase family protein | 0.0143 | 0.8095 | 0.8072 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0049 | 0.0335 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0045 | 0 | 0.5 |
Giardia lamblia | High cysteine protein | 0.0046 | 0.0117 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Onchocerca volvulus | Peroxidasin homolog | 0.0143 | 0.8095 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0049 | 0.0335 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0143 | 0.8095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.8095 | 0.8072 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 1.8 uM | Cytotoxicity against human MT2 cells infected with HIV1 3B by MTT assay | ChEMBL. | 22081993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.