Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.98 | 0.9799 |
Onchocerca volvulus | 0.0295 | 0.98 | 0.5 | |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0241 | 0.7826 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0301 | 1 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0033 | 0.0033 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.1932 | 0.1945 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0241 | 0.7826 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0033 | 0.0033 |
Leishmania major | squalene monooxygenase-like protein | 0.0241 | 0.7826 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0033 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0033 | 0.0042 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0027 | 0 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0241 | 0.7826 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0033 | 0.5 |
Brugia malayi | hypothetical protein | 0.0295 | 0.98 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0033 | 0.0042 |
Trypanosoma brucei | RNA helicase, putative | 0.0081 | 0.1972 | 0.2519 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0033 | 0.0033 |
Giardia lamblia | Rrm3p helicase | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.1972 | 0.1972 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0301 | 1 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0033 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | snurportin 1 | 0.0301 | 1 | 1 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0027 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.