Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0622 | 0.04 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.1689 | 0.9314 | 1 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.1689 | 0.9314 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1771 | 1 | 1 |
Loa Loa (eye worm) | beta-glucuronidase | 0.1642 | 0.8914 | 0.9231 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.1771 | 1 | 1 |
Brugia malayi | Beta-glucuronidase precursor | 0.1642 | 0.8914 | 0.9571 |
Entamoeba histolytica | beta-galactosidase, putative | 0.1197 | 0.52 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.