Detailed view for Bm1_01460

Basic information

TDR Targets ID: 244369
Brugia malayi, Beta-glucuronidase precursor
Source Database / ID:  GenBank

pI: 7.3969 | Length (AA): 116 | MW (Da): 13469 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02836   Glycosyl hydrolases family 2, TIM barrel domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0043169   cation binding  
GO:0003824   catalytic activity  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 114 3hn3 (A) 521 632 51.00 0 0.97 1.56886 -0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131767)

Species Accession Gene Product
Brugia malayi Bm1_53975   Glycosyl hydrolases family 2, sugar binding domain containing protein
Brugia malayi Bm1_01460   Beta-glucuronidase precursor
Caenorhabditis elegans CELE_Y105E8B.9   Protein Y105E8B.9
Drosophila melanogaster Dmel_CG15117   CG15117 gene product from transcript CG15117-RA
Drosophila melanogaster Dmel_CG2135   CG2135 gene product from transcript CG2135-RA
Escherichia coli b1617   beta-D-glucuronidase
Homo sapiens ENSG00000169919   glucuronidase, beta
Loa Loa (eye worm) LOAG_14263   beta-glucuronidase
Loa Loa (eye worm) LOAG_11024   hypothetical protein
Loa Loa (eye worm) LOAG_12529   glycosyl hydrolase family 2
Mus musculus ENSMUSG00000025534   glucuronidase, beta

Essentiality

Bm1_01460 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b1617 Escherichia coli non-essential goodall
CELE_Y105E8B.9 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Beta-glucuronidase Compounds References
Homo sapiens glucuronidase, beta Compounds References
Sinorhizobium meliloti Beta-galactosidase Compounds References
Bos taurus Beta-glucuronidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.195 0.9265 0.9716
0.2048 0.7894 0.9715
0.1197 0.4511 0.9712
0.0247 0.9164 0.9659
0.1651 0.9266 0.9716
0.0241 0.9152 0.967
0.0502 0.8869 0.8943
0.0229 0.6472 0.6457
0.1338 0.9263 0.9715
0.3283 0.9265 0.9716
0.0449 0.6844 0
0.0275 0.7738 0
0.0711 0.2877 0.7004
0.0697 0.4237 0.7052
0.0192 0.5347 0.5347
0.069 0.3823 0.9711
0.0674 0.567 0.971
0.0686 0.8548 0.9707
0.0243 0.2972 0.2967
0.0912 0.8155 0
0.0475 0.8869 0
0.117 0.2738 0.9711
0.0716 0.2905 0.9709
0.0698 0.27 0.971
0.0681 0.3834 0.9712
0.1716 0.5598 0.9714
0.0225 0.2995 0.9705
0.0336 0.353 0.9425
0.1649 0.9251 0.9706
0.0473 0.8155 0
0.0704 0.9177 0.967
0.0716 0.4602 0.9713
0.3289 0.7995 0.9715
0.2119 0.9252 0.9707
0.0918 0.5817 0.9712
0.0221 0.3038 0.3018
0.0224 0.2518 0.4267
0.0504 0.297 0.7754
0.045 0.5578 0.8733
0.0225 0.9032 0.9032
0.3255 0.9264 0.9716
0.1178 0.8869 0
0.1438 0.9265 0.9715
0.1716 0.5598 0.9714
0.0221 0.3038 0.3018
0.092 0.3884 0.9712
0.1197 0.4511 0.9712
0.068 0.4019 0.9712
0.0471 0.5051 0.7718
0.0932 0.6512 0.9713
0.0921 0.4777 0.9712
0.0225 0.3863 0.9706
0.0691 0.8914 0.9571
0.0223 0.2654 0.3551
0.0226 0.6669 0.6669
0.0445 0.3154 0.9363
0.1399 0.9265 0.9716
0.0159 0.545 0.5448
0.0691 0.2878 0.9711
0.1197 0.4511 0.9712
0.0483 0.7078 0.9711
0.0719 0.7577 0.9712
0.0691 0.8155 0
0.0701 0.8155 0
0.1156 0.9245 0.9707
0.3429 0.9265 0.9716
0.0716 0.4602 0.9713
0.0863 0.3013 0.9713
0.0235 0.2591 0.6339
0.016 0.5379 0.5379
0.0495 0.6003 0.9695
0.1646 0.9112 0.9571
0.0275 0.3172 0.6099
0.0252 0.2826 0.9695
0.0275 0.4416 0.9706
0.1157 0.6937 0.971
0.0275 0.3385 0.9704
0.1197 0.4511 0.9712
0.1845 0.7738 0
0.096 0.7738 0
0.0475 0.9251 0.971
0.0501 0.5497 0.9706
0.0162517 0.367781 0.371774
0.0452 0.4778 0.4828
0.026 0.2982 0.9685
0.0483 0.4967 0.9571
0.0228 0.5501 0.6038
0.0708 0.2976 0.971
0.0275 0.5632 0.97
0.0275 0.8155 0
0.1854 0.8155 0
0.0962 0.2842 0.9711
0.1197 0.4563 0.4563
0.1415 0.7738 0
0.32 0.9265 0.9716
0.0235 0.2613 0.9011
0.0696 0.2666 0.9643
0.0235 0.3204 0.9702
0.0714 0.9003 0.9586
0.0221 0.2688 0.2964
0.0157 0.5539 0.5539
0.0922 0.4314 0.9712
0.0474 0.423 0.4364
0.0781 0.9003 0.9571
0.3238 0.4303 0.9715
0.0227 0.7148 0.7267
0.0222 0.2723 0.3889
0.186926 0.823453 1
0.0444 0.2594 0.8709
0.3256 0.9265 0.9716
0.0682 0.5478 0.9712
0.0897 0.5451 0.9712
0.0318 0.4689 0.9476
0.1376 0.9264 0.9713
0.022 0.8982 0.9571
0.0459 0.4785 0
0.0162 0.5452 0.5452
0.0445 0.8869 0
0.0449 0.8914 0.9571
0.0231 0.9259 0.9712
0.119 0.9258 0.9713
0.3485 0.9265 0.9716
0.0711 0.2877 0.7004
0.0674 0.567 0.971
0.2266 0.9253 0.971
0.1375 0.7738 0
0.3238 0.4303 0.9715
0.0459 0.2847 0.9713
0.0735 0.7738 0
0.0948 0.2758 0.969
0.0708 0.925 0.971
0.0703 0.7738 0
0.0504 0.297 0.7754
0.0225 0.4772 0.9691
0.0275 0.8155 0
0.0228 0.5491 0.9706
0.1197 0.4511 0.9712
0.1017 0.2934 0.9435
0.0702 0.4204 0.9391
0.0676 0.4193 0.4319
0.0952 0.3786 0.3786
0.045 0.9201 0.9711
0.0503 0.751 0.9693
0.0224 0.2518 0.4267
0.3289 0.7995 0.9715
0.0249 0.2688 0.5299
0.0457 0.4847 0.971
0.0449 0.264 0.9685
0.0495 0.3095 0.9713
0.0469 0.8155 0
0.1156 0.9245 0.9707
0.0244 0.2739 0.3764
0.0504 0.297 0.7754
0.1132 0.9241 0.9706
0.2946 0.4534 0.9714
0.0714 0.7738 0
0.0275 0.8155 0
0.1205 0.799 0.799
0.1197 0.4563 0.4563
0.1205 0.799 0.799
0.0468 0.4966 0.9711
0.0221 0.9209 0.9693
0.0674 0.567 0.971
0.0459 0.4785 0
0.0275 0.2984 0.9673
0.046 0.9236 0.9704
0.0747 0.9248 0.9571
0.0467 0.9164 0.9647
0.1902 0.8155 0
0.1642 0.8914 0.9571
0.0221 0.3038 0.3018
0.0224 0.8073 0.9654
0.3517 0.9264 0.9716
0.0703 0.7738 0
0.1017 0.2934 0.9435
0.3047 0.9265 0.9716
0.2708 0.7836 0.9715
0.2946 0.4534 0.9714
0.118 0.5059 0
0.3259 0.9265 0.9716
0.0445 0.6322 0.9683
0.3513 0.9264 0.9716
0.0246 0.2713 0.9682
0.0927 0.2769 0.9016
0.0919 0.7681 0.7876
0.0908 0.9254 0.9709
0.0224 0.2518 0.4267
0.0483 0.4967 0.9571
0.0243 0.8914 0.9571
0.1142 0.4681 0.9713
0.0959 0.4457 0.9712
0.025 0.2718 0.9682
0.0237 0.287 0.9698
0.0944 0.287 0.971
0.0695 0.4234 0.971
0.0448 0.453 0.9711
0.0444 0.8155 0
0.0222 0.3721 0.9688
0.0221 0.3748 0.9691
0.1205 0.4533 0.9713
0.0255 0.2951 0.9703
0.0192 0.5498 0.5498
0.3546 0.5761 0.9715
0.0446 0.9143 0.9666
0.3238 0.4303 0.9715
0.0451 0.9237 0.9704
0.0666 0.3877 0.9714
0.0922 0.4314 0.9712
0.2048 0.7894 0.9715
0.0959 0.4457 0.9712
0.0449 0.2553 0.8397
0.0935 0.5653 0.9712
0.0275 0.9139 0.9664
0.025 0.2948 0.2886
0.0682 0.2547 0.7116
0.0701 0.8155 0
0.1075 0.2934 0.9435
0.1142 0.4681 0.9713
0.1149 0.9023 0.9571
0.0445 0.3154 0.9363
0.0661 0.3815 0.9712
0.0221 0.3038 0.3018
0.038 0.3427 0.6198
0.0224 0.8155 0
0.1926 0.8914 0.9571
0.1205 0.799 0.799
0.0669 0.5831 0.9571
0.0445 0.6322 0.9683
0.2164 0.9258 0.9712
0.0723 0.8804 0.9714
0.0674 0.567 0.971
0.0461 0.3176 0.9711
0.095 0.3326 0.3326
0.0231 0.5026 0.6872
0.0452 0.4801 0.4949
0.1416 0.9263 0.9715
0.294 0.7489 0.9709
0.2521 0.9264 0.9716
0.1661 0.8914 0.9571
0.0708 0.925 0.971
0.0192 0.5347 0.5347
0.0275 0.2654 0.9687
0.0225 0.3563 0.1548
0.0257 0.3109 0.8609
0.0674 0.567 0.971
0.016 0.5486 0.5481
0.0463 0.5671 0.9695
0.048 0.2764 0.5844
0.2946 0.4534 0.9714
0.1197 0.4563 0.4563
0.0235 0.2629 0.9692
0.095 0.3326 0.3326
0.0225 0.3563 0.1548
0.3132 0.9265 0.9716
0.195 0.9265 0.9716
0.0175 0.5001 0.5001
0.0223 0.2606 0.9704
0.1673 0.9265 0.9716
0.0261 0.4916 0.9714
0.0226 0.6702 0.6673
0.0275 0.8155 0
0.0221 0.2676 0.2952
0.0732 0.3559 0.6084
0.1197 0.4563 0.4563
0.0143 0.3802 0.4835
0.3157 0.9265 0.9716
0.0222 0.3547 0.3547
0.0389 0.2571 0.9181
0.0336 0.353 0.9425
0.0948 0.5953 0.9708
0.0701 0.8155 0
0.0691 0.8155 0
0.0979 0.9196 0.9661
0.0444 0.2894 0.6343
0.119 0.9258 0.9713
0.0275 0.8155 0
0.2708 0.7836 0.9715
0.0453 0.5714 0.9712
0.0235 0.2591 0.6339
0.024 0.2893 0.2956
0.045 0.5192 0.8712
0.1821 0.9249 0.9705
0.0711 0.2877 0.7004
0.0235 0.2629 0.9692
0.0275 0.6591 0.9709
0.1197 0.4511 0.9712
0.0228 0.5491 0.9706
0.0169 0.2699 0.3123
0.0933 0.5679 0.9711
0.0715 0.8155 0
0.0508 0.635 0.635
0.1911 0.9263 0.9715
0.1611 0.6617 0.9712
0.0275 0.8155 0
0.1075 0.2934 0.9435
0.048 0.348 0.971
0.0224 0.2518 0.4267
0.0488 0.9214 0.9695
0.0271 0.4195 0.4269
0.3238 0.4303 0.9715
0.1716 0.5598 0.9714
0.0258 0.3612 0.969
0.32 0.9265 0.9716
0.3485 0.9265 0.9716
0.0452 0.2522 0.6509
0.3256 0.9265 0.9716
0.3513 0.9264 0.9716
0.0328 0.5227 0.9476
0.019 0.3563 0.1548
0.3289 0.9265 0.9716
0.096 0.7738 0
0.1197 0.4563 0.4563
0.022 0.2638 0.3066
0.2708 0.7836 0.9715
0.119 0.7256 0.9715
0.0231 0.9259 0.9712
0.0495 0.5342 0.9712
0.0504 0.297 0.7754
0.2059 0.9264 0.9715
0.0674 0.567 0.971
0.0701 0.8155 0
0.0669 0.6715 0.9702
0.0779 0.9002 0.9571
0.1205 0.799 0.799
0.0221 0.9209 0.9693
0.0231 0.2824 0.9048
0.0504 0.297 0.7754
0.0275 0.8155 0
0.3043 0.9265 0.9716
0.0691 0.8914 0.9571
0.0454 0.2836 0.4362
0.0246 0.4323 0.9686
0.0223 0.4903 0.9704
0.045 0.3702 0.3778
0.019 0.3563 0.1548
0.0165 0.3218 0.4007
0.0223 0.266 0.9708
0.0549 0.7738 0
0.0477 0.2843 0.9711
0.02 0.8914 0.9571
0.0159 0.545 0.5448
0.1716 0.5598 0.9714
0.0765 0.8869 0
0.1908 0.9137 0.9571
0.2992 0.9264 0.9716
0.1153 0.9261 0.9714
0.0264 0.4007 0.4078
0.0275 0.2675 0.9698
0.0477 0.6906 0.971
0.0687 0.5905 0.971
0.3176 0.9265 0.9716
0.0936 0.5031 0.9712
0.0226 0.273 0.9696
0.0465 0.563 0.9709
0.0496 0.9232 0.9693

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_01460 (Brugia malayi), Beta-glucuronidase precursor
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