Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0509 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0131 | 0.1838 | 0.1838 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.1714 | 0.1714 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0509 | 1 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0509 | 1 | 1 |
Onchocerca volvulus | 0.0293 | 0.5336 | 0.5336 | |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0171 | 0.2708 | 0.5 |
Onchocerca volvulus | 0.0259 | 0.4599 | 0.4599 | |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0509 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0305 | 0.5597 | 0.5597 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0293 | 0.5336 | 0.5336 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0171 | 0.2708 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0171 | 0.2708 | 0.2708 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0171 | 0.2708 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5336 | 0.5336 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1838 | 0.1838 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.5336 | 0.5336 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0171 | 0.2708 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0171 | 0.2708 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0171 | 0.2708 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0509 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0171 | 0.2708 | 0.2708 |
Brugia malayi | Trypsin family protein | 0.0293 | 0.5336 | 0.5336 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 10.7 uM | Cytotoxic activity against human PBMC cells | ChEMBL. | 18316517 |
IC50 (binding) | uM | In vitro anti-HIV integrase activity of the compound was tested against integration(strand transfer) of target plasmid; Not determined | ChEMBL. | 9667973 |
IC50 (binding) | 0 uM | In vitro anti-HIV integrase activity of the compound was tested against integration(strand transfer) of target plasmid; Not determined | ChEMBL. | 9667973 |
IC50 (binding) | = 0.26 uM | HIV integrase inhibitory potency of the compound was evaluated as IC50 on 3' processing of target DNA. | ChEMBL. | 9667973 |
IC50 (binding) | = 0.26 uM | HIV integrase inhibitory potency of the compound was evaluated as IC50 on 3' processing of target DNA. | ChEMBL. | 9667973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.