Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.091 | 0.7729 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1152 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1152 | 1 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.091 | 0.7729 | 1 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0316 | 0.2156 | 0.2664 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0086 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.091 | 0.7729 | 0.7698 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.111 | 0.1288 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.091 | 0.7729 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0086 | 0 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0086 | 0 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.091 | 0.7729 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1152 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.111 | 0.1288 |
Brugia malayi | Telomerase reverse transcriptase | 0.023 | 0.1346 | 0.123 |
Loa Loa (eye worm) | hypothetical protein | 0.0589 | 0.4715 | 0.4644 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.091 | 0.7729 | 0.7698 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.111 | 0.1288 |
Giardia lamblia | Telomerase catalytic subunit | 0.0086 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.111 | 0.1288 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 80 uM | PUBCHEM_BIOASSAY: SAR analysis of small molecule inhibitors of hexokinase domain containing I (HKDC1) in the hexokinase 1 selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493160, AID493190] | ChEMBL. | No reference |
IC50 (functional) | > 80 uM | PUBCHEM_BIOASSAY: SAR analysis of small molecule inhibitors of hexokinase domain containing I (HKDC1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493160, AID493190] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.