Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | phospho-N-acetylmuramoyl-pentapeptide transferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Mycobacterium leprae | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | Get druggable targets OG5_131597 | All targets in OG5_131597 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0896 | 0.5863 | 0.5 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0896 | 0.5863 | 0.5 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0341 | 0.181 | 0.5 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.1463 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0156 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0464 | 0.0464 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.0103 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0 | 0.5 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | 0.0341 | 0.181 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0 | 0.5 |
Mycobacterium leprae | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.0896 | 0.5863 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0107 | 0.0103 | 0.0103 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0156 | 0.0464 | 0.0464 |
Onchocerca volvulus | 0.1463 | 1 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0156 | 0.0464 | 0.0464 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0896 | 0.5863 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 37 ng ml-1 | Inhibitory activity against translocase I | ChEMBL. | 14611838 |
IC50 (binding) | = 37 ng ml-1 | Inhibitory activity against translocase I | ChEMBL. | 14611838 |
MIC (functional) | = 2 ug ml-1 | Antimycobacterial activity against M. intracellulare (ATCC1954 E-3) | ChEMBL. | 14611838 |
MIC (functional) | = 2 ug ml-1 | Antimycobacterial activity against M. kansasii (ATCC12478) | ChEMBL. | 14611838 |
MIC (functional) | = 4 ug ml-1 | Antimycobacterial activity of the compound against M. avium (NIHJ1605) | ChEMBL. | 14611838 |
MIC (functional) | = 6.25 ug ml-1 | Antimycobacterial activity against Mycobacterium smegmatis (SANK 75075) | ChEMBL. | 14611838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.