Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0021 | 0.0046 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.027 | 0.3703 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0021 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0021 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0204 | 0.045 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0021 | 0.0089 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0586 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0021 | 0.0014 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0021 | 0.0046 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0021 | 0.0014 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0021 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0017 | 0.0037 |
Onchocerca volvulus | 0.0097 | 0.1006 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0586 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0204 | 0.045 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.0204 | 0.2714 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.0586 | 0.0566 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0021 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0046 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0021 | 0.0046 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0694 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.0694 | 0.2956 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0021 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0097 | 0.1006 | 0.4289 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0204 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0204 | 0.045 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0204 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0204 | 0.2761 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.027 | 0.0843 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0046 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0021 | 0.0089 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.3021 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0021 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0204 | 0.045 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.0586 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0046 |
Echinococcus multilocularis | tumor protein p63 | 0.0661 | 1 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.027 | 0.025 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0021 | 0.0014 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0046 | 0.0204 | 0.0622 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0046 | 0.0204 | 0.2761 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0694 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.027 | 0.0843 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0021 | 0.0014 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0694 | 0.0674 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.0694 | 0.0674 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0204 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0694 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1006 | 0.2227 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0046 | 0.0204 | 0.0622 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0248 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0017 | 0.0037 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0248 | 0.0549 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0694 | 0.2892 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0694 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.1637 | 0.6978 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0021 | 0.0064 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0021 | 0.0014 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.0694 | 0.2892 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0017 | 0.0037 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0021 | 0.0046 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.0694 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.027 | 0.025 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0021 | 0.0064 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0046 | 0.0204 | 0.2761 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0586 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0021 | 0.0014 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0021 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0021 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0204 | 0.045 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0046 | 0.0204 | 0.2761 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0694 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0204 | 0.2761 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0021 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0021 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0694 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.2347 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0017 | 0.0037 |
Onchocerca volvulus | 0.0046 | 0.0204 | 0.1853 | |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0021 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.0204 | 0.2761 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0694 | 0.1535 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.1637 | 0.6978 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0046 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.0694 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0021 | 0.0064 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.0694 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0181 | 0.2347 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0046 | 0.0204 | 0.2761 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.452 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0204 | 0.045 |
Echinococcus multilocularis | WD repeat containing protein 48 | 0.0317 | 0.452 | 0.4508 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0021 | 0.0064 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0204 | 0.2761 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0021 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0586 | 0.2498 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0021 | 0.5 |
Brugia malayi | Hypothetical WD-repeat protein F35G12.4 in chromosome III | 0.0317 | 0.452 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0021 | 0.0046 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.0586 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.0694 | 0.1535 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0021 | 0.0014 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0248 | 0.0549 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0021 | 0.0046 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.0586 | 0.2498 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0021 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0248 | 0.0549 |
Echinococcus granulosus | WD repeat containing protein 48 | 0.0317 | 0.452 | 0.4508 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0021 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0017 | 0.0037 |
Brugia malayi | hypothetical protein | 0.007 | 0.0586 | 0.1297 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.0204 | 0.2714 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.