Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium leprae | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 437 aa | 397 aa | 28.5 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0026 | 0.0349 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0057 | 0.2023 | 1 |
Brugia malayi | glutathione reductase | 0.0052 | 0.1769 | 0.8744 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0583 | 0.1652 |
Trypanosoma brucei | protein kinase, putative | 0.0057 | 0.2023 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0133 | 0.6117 | 0.6775 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0057 | 0.2023 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0119 | 0.5396 | 0.5929 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.1769 | 0.1472 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0.2023 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.1769 | 0.8483 |
Mycobacterium tuberculosis | Probable reductase | 0.0119 | 0.5396 | 0.5929 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0184 | 0.8862 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0057 | 0.2023 | 0.1735 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0119 | 0.5396 | 0.5929 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0583 | 0.1652 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.1769 | 0.8235 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0133 | 0.6117 | 0.6775 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0057 | 0.2023 | 0.1735 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0.2023 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.1769 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0119 | 0.5396 | 0.5929 |
Leishmania major | trypanothione reductase | 0.0052 | 0.1769 | 0.8235 |
Brugia malayi | hypothetical protein | 0.003 | 0.0583 | 0.2883 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0057 | 0.2023 | 0.1735 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0057 | 0.2023 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0052 | 0.1769 | 0.8235 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.1769 | 0.1668 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0057 | 0.2023 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.1769 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0057 | 0.2023 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0057 | 0.2023 | 1 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0026 | 0.0349 | 0.5 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0026 | 0.0349 | 0.1723 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0052 | 0.1769 | 0.8235 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0057 | 0.2023 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0133 | 0.6117 | 0.6775 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0057 | 0.2023 | 0.1735 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.1769 | 0.8235 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0057 | 0.2023 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0119 | 0.5396 | 0.5929 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.1769 | 0.8744 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0184 | 0.8862 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.1769 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0057 | 0.2023 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0119 | 0.5396 | 0.5929 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0057 | 0.2023 | 0.1735 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.1769 | 0.1472 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0583 | 0.1652 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0119 | 0.5396 | 0.5929 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0184 | 0.8862 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0133 | 0.6117 | 0.6775 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.1769 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0184 | 0.8862 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0583 | 0.1402 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0184 | 0.8862 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0184 | 0.8862 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | 3.13 uM | PubChem BioAssay. Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.0891 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.6513 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.