Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0324 | 0.3369 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0324 | 0.3369 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0129 | 0 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0129 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.071 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0324 | 0.3369 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0129 | 0 | 0.5 |
Trypanosoma brucei | aurora B kinase | 0.0129 | 0 | 0.5 |
Leishmania major | protein kinase, putative | 0.0129 | 0 | 0.5 |
Toxoplasma gondii | aurora kinase | 0.0129 | 0 | 0.5 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0324 | 0.3369 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0129 | 0 | 0.5 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0324 | 0.3369 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0129 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0129 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0129 | 0 | 0.5 |
Loa Loa (eye worm) | TTK protein kinase | 0.0324 | 0.3369 | 0.3369 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0324 | 0.3369 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0324 | 0.3369 | 0.3369 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0129 | 0 | 0.5 |
Giardia lamblia | Kinase, TTK | 0.0324 | 0.3369 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0129 | 0 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0129 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.