Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3908 | 0.3908 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0305 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0723 | 0.0723 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6201 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0305 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0305 | 1 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3908 | 0.3908 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0305 | 1 | 0.5 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0305 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.013 | 0.3371 | 0.3371 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3908 | 0.3908 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0305 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6201 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0305 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0723 | 0.0723 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0305 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0723 | 0.0723 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0305 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6201 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.013 | 0.3371 | 0.3371 |
Echinococcus granulosus | geminin | 0.0205 | 0.6201 | 0.5 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0305 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.0596 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.5929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.