TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 261.273 | Formula: C14H15NO4
H donors: 1 H acceptors: 3 LogP: 1.63 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1ccccc1)CC(=O)NC1CCOC1=O
InChi: 1S/C14H15NO4/c16-11(8-10-4-2-1-3-5-10)9-13(17)15-12-6-7-19-14(12)18/h1-5,12H,6-9H2,(H,15,17)
InChiKey: SZKJWOMSLREKNK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	SRC-1	0.0435	0.7185	0.677
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0148	0.1286	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0148	0.1286	0.0362
Echinococcus multilocularis	integrin linked protein kinase	0.0148	0.1286	0.0362
Onchocerca volvulus		0.0287	0.4151	0.4856
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0287	0.4151	0.5016
Plasmodium falciparum	protein kinase, putative	0.0149	0.1318	1
Brugia malayi	Protein kinase domain containing protein	0.0222	0.2813	0.1752
Loa Loa (eye worm)	hypothetical protein	0.0572	1	1
Onchocerca volvulus		0.0287	0.4151	0.4856
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0287	0.4151	0.5042
Giardia lamblia	Kinase, NEK	0.0148	0.1286	1
Echinococcus granulosus	tensin	0.0287	0.4151	0.5016
Echinococcus multilocularis	SH2 motif	0.0287	0.4151	0.5042
Entamoeba histolytica	serine/threonine kinase, putative	0.0148	0.1286	0.0312
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0287	0.4151	0.5042
Entamoeba histolytica	tyrosin kinase, putative	0.0148	0.1286	0.0312
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0287	0.4151	0.5042
Loa Loa (eye worm)	TK protein kinase	0.0435	0.7185	0.677
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0435	0.7185	1
Entamoeba histolytica	ankyrin repeat protein	0.0148	0.1286	0.0312
Mycobacterium tuberculosis	Possible nitrate/nitrite response transcriptional regulatory protein NarL	0.0159	0.151	0.5
Brugia malayi	SH2 domain containing protein	0.0435	0.7185	0.677
Schistosoma mansoni	GTPase activating protein	0.0287	0.4151	0.4856
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0435	0.7185	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0435	0.7185	0.677
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0148	0.1286	0.036
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0148	0.1286	0.0362
Mycobacterium tuberculosis	Probable transcriptional regulatory protein	0.0159	0.151	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Schistosoma mansoni	SH2A	0.0287	0.4151	0.4856
Schistosoma mansoni	tyrosine kinase	0.0435	0.7185	1
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0437	0.7217	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0435	0.7185	0.9949
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0287	0.4151	0.5042
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Plasmodium falciparum	protein kinase, putative	0.0148	0.1286	0.8572
Onchocerca volvulus		0.0287	0.4151	0.4856
Brugia malayi	Protein kinase domain containing protein	0.0435	0.7185	0.677
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0148	0.1286	1
Schistosoma mansoni	tensin	0.0287	0.4151	0.4856
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	AGC family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.1286	0.4573
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0148	0.1286	0.0312
Brugia malayi	hypothetical protein	0.0435	0.7185	0.677
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Echinococcus multilocularis	tyrosine protein kinase csk	0.0148	0.1286	0.0362
Giardia lamblia	Kinase, NEK	0.0148	0.1286	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0148	0.1286	0.036
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0435	0.7185	0.9949
Entamoeba histolytica	tyrosin kinase, putative	0.0148	0.1286	0.0312
Brugia malayi	SH2 domain containing protein	0.0287	0.4151	0.3287
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Schistosoma mansoni	protein kinase	0.0149	0.1318	0.0054
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0149	0.1318	0.7868
Schistosoma mansoni	tensin-related	0.0287	0.4151	0.4856
Entamoeba histolytica	hypothetical protein	0.0148	0.1286	0.0312
Brugia malayi	protein-tyrosine kinase	0.0435	0.7185	0.677
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0287	0.4151	0.5042
Entamoeba histolytica	serine/threonine kinase, putative	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Schistosoma mansoni	growth factor receptor-bound protein	0.0287	0.4151	0.4856
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0181	0.1965	0.0779
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Echinococcus granulosus	tyrosine protein kinase HCK	0.0148	0.1286	0.036
Echinococcus multilocularis	tensin	0.0287	0.4151	0.5042
Schistosoma mansoni	growth factor receptor-bound protein	0.0287	0.4151	0.4856
Trichomonas vaginalis	AGC family protein kinase	0.0222	0.2813	1
Echinococcus granulosus	activin receptor type	0.0149	0.1318	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0435	0.7185	0.677
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0287	0.4151	0.3287
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0208	0.2531	0.1429
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0435	0.7185	1
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0435	0.7185	0.9949
Brugia malayi	Variant SH3 domain containing protein	0.0301	0.4432	0.361
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0287	0.4151	0.3287
Toxoplasma gondii	AGC kinase	0.0208	0.2531	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0435	0.7185	0.677
Brugia malayi	SH2 domain containing protein	0.0435	0.7185	0.677
Schistosoma mansoni	adapter molecule crk	0.0287	0.4151	0.4856
Entamoeba histolytica	hypothetical protein	0.0148	0.1286	0.0312
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0139	0.1097	0.0051
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Echinococcus multilocularis		0.0287	0.4151	0.5042
Brugia malayi	Variant SH3 domain containing protein	0.0287	0.4151	0.3287
Schistosoma mansoni	tyrosine kinase	0.0435	0.7185	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0148	0.1286	0.4573
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0149	0.1318	0.7868
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Brugia malayi	Variant SH3 domain containing protein	0.0287	0.4151	0.3287
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Loa Loa (eye worm)	TK/FER protein kinase	0.0435	0.7185	0.677
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0435	0.7185	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0148	0.1286	0.0362
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0148	0.1286	0.0362
Schistosoma mansoni	signal transduction protein lnk-related	0.0287	0.4151	0.4856
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (probably LuxR/UhpA-family)	0.0159	0.151	0.5
Schistosoma mansoni	tensin	0.0287	0.4151	0.4856
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	SHC transforming protein 3	0.0287	0.4151	0.5016
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0148	0.1286	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3848	0.294
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0148	0.1286	0.036
Entamoeba histolytica	hypothetical protein	0.0148	0.1286	0.0312
Entamoeba histolytica	ankyrin repeat protein	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	AGC family protein kinase	0.0222	0.2813	1
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	SH2 motif	0.0287	0.4151	0.5016
Onchocerca volvulus		0.0287	0.4151	0.4856
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0287	0.4151	0.5016
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Giardia lamblia	Protein 21.1	0.0148	0.1286	1
Echinococcus multilocularis	tyrosine protein kinase	0.0148	0.1286	0.0362
Brugia malayi	Tensin	0.0287	0.4151	0.3287
Echinococcus multilocularis	protein tyrosine kinase	0.0148	0.1286	0.0362
Echinococcus multilocularis	tyrosine kinase	0.0435	0.7185	1
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Echinococcus granulosus	serine threonine protein kinase nrc	0.0139	0.1097	0.0051
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0287	0.4151	0.5016
Plasmodium falciparum	tyrosine kinase-like protein	0.0148	0.1286	0.8572
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0435	0.7185	0.9949
Schistosoma mansoni	vav2	0.0301	0.4432	0.5333
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Brugia malayi	hypothetical protein	0.0287	0.4151	0.3287
Brugia malayi	Sex muscle abnormal protein 5	0.0287	0.4151	0.3287
Loa Loa (eye worm)	SH2 domain-containing protein	0.0287	0.4151	0.3287
Brugia malayi	SH2 domain containing protein	0.0287	0.4151	0.3287
Mycobacterium tuberculosis	Possible two component transcriptional regulatory protein (probably LuxR-family)	0.0159	0.151	0.5
Echinococcus multilocularis	SH2 motif	0.0287	0.4151	0.5042
Entamoeba histolytica	protein kinase, putative	0.0222	0.2813	0.2819
Loa Loa (eye worm)	TK/FER protein kinase	0.0435	0.7185	0.677
Schistosoma mansoni	tyrosine kinase	0.0435	0.7185	1
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	tyrosine protein kinase csk	0.0148	0.1286	0.036
Loa Loa (eye worm)	TK/FER protein kinase	0.0435	0.7185	0.677
Trypanosoma brucei	protein kinase, putative	0.0149	0.1318	0.0207
Onchocerca volvulus		0.0435	0.7185	1
Echinococcus multilocularis	protein kinase	0.0148	0.1286	0.0362
Onchocerca volvulus		0.0435	0.7185	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0148	0.1286	0.036
Entamoeba histolytica	hypothetical protein, conserved	0.0148	0.1286	0.0312
Mycobacterium leprae	PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	0.0159	0.151	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Brugia malayi	Protein kinase domain containing protein	0.0435	0.7185	0.677
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0148	0.1286	0.0362
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0149	0.1318	0.0412
Echinococcus multilocularis	activin receptor type	0.0149	0.1318	0.0414
Giardia lamblia	Kinase	0.0148	0.1286	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0148	0.1286	0.036
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.1286	0.4573
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0435	0.7185	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0155	0.1428	0.0545
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0435	0.7185	1
Echinococcus granulosus	serine/threonine protein kinase	0.0152	0.1378	0.0509
Trichomonas vaginalis	TK family protein kinase	0.0148	0.1286	0.4573
Echinococcus multilocularis	protein kinase	0.0148	0.1286	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0148	0.1286	0.036
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0287	0.4151	0.3287
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	hypothetical protein	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus multilocularis	tyrosine protein kinase csk	0.0148	0.1286	0.0362
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0139	0.1097	0.0052
Brugia malayi	Tyrosine-protein kinase abl-1	0.0435	0.7185	0.677
Echinococcus multilocularis	epidermal growth factor receptor	0.0148	0.1286	0.0362
Entamoeba histolytica	serine/threonine kinase, putative	0.0148	0.1286	0.0312
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0287	0.4151	0.5016
Mycobacterium ulcerans	hypothetical protein	0.0159	0.151	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Echinococcus granulosus	tyrosine protein kinase shark	0.0435	0.7185	0.9949
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0152	0.1378	0.0462
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0148	0.1286	0.036
Echinococcus multilocularis	tyrosine protein kinase csk	0.0148	0.1286	0.0362
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0148	0.1286	0.036
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0148	0.1286	0.0362
Onchocerca volvulus		0.0287	0.4151	0.4856
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0287	0.4151	0.5042
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0435	0.7185	1
Echinococcus multilocularis	heat shock protein 70	0.0148	0.1286	0.0362
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0287	0.4151	0.3287
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0148	0.1286	0.0362
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0148	0.1286	0.0362
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0301	0.4432	0.361
Echinococcus granulosus	insulin receptor	0.0148	0.1286	0.036
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0148	0.1286	0.4573
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Trypanosoma cruzi	Protein kinase B	0.0152	0.1378	1
Loa Loa (eye worm)	STAT protein	0.0287	0.4151	0.3287
Echinococcus granulosus	natriuretic peptide receptor 1	0.0148	0.1286	0.036
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0287	0.4151	0.4856
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0435	0.7185	0.9949
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0287	0.4151	0.4856
Loa Loa (eye worm)	TK/FER protein kinase	0.0435	0.7185	0.677
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus multilocularis	insulin receptor	0.0148	0.1286	0.0362
Echinococcus granulosus	hypothetical protein	0.0287	0.4151	0.5016
Trichomonas vaginalis	AGC family protein kinase	0.0222	0.2813	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0435	0.7185	1
Echinococcus multilocularis	FL cytokine receptor	0.0148	0.1286	0.0362
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0287	0.4151	0.3287
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0287	0.4151	0.4856
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0148	0.1286	0.0362
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Onchocerca volvulus		0.0435	0.7185	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0148	0.1286	0.036
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0148	0.1286	0.0362
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0287	0.4151	0.5042
Entamoeba histolytica	serine/threonine kinase, putative	0.0148	0.1286	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.1286	0.4573
Echinococcus granulosus	integrin linked protein kinase	0.0148	0.1286	0.036
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Echinococcus granulosus	c src tyrosine kinase	0.0435	0.7185	0.9949
Schistosoma mansoni	serine/threonine-protein kinase	0.0152	0.1378	0.0155
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0148	0.1286	0.036
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0152	0.1378	0.0462
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0222	0.2813	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	STE family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Echinococcus granulosus	NCK adaptor protein	0.0287	0.4151	0.5016
Trypanosoma cruzi	protein kinase, putative	0.0148	0.1286	0.6744
Schistosoma mansoni	hypothetical protein	0.0287	0.4151	0.4856
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0435	0.7185	1
Echinococcus granulosus	protein tyrosine kinase	0.0148	0.1286	0.036
Brugia malayi	Protein kinase domain containing protein	0.0435	0.7185	0.677
Brugia malayi	SH2 domain containing protein	0.0287	0.4151	0.3287
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Entamoeba histolytica	protein kinase, putative	0.0155	0.1428	0.0545
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0287	0.4151	0.5016
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (LuxR-family)	0.0159	0.151	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Brugia malayi	SH2 domain containing protein	0.0287	0.4151	0.3287
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0149	0.1318	0.0414
Echinococcus granulosus	activated cdc42 kinase 1	0.0148	0.1286	0.036
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0435	0.7185	1
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0174	0.1832	0.0924
Echinococcus granulosus	epidermal growth factor receptor	0.0148	0.1286	0.036
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0148	0.1286	0.0362
Echinococcus multilocularis	epidermal growth factor receptor	0.0148	0.1286	0.0362
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0287	0.4151	0.5016
Schistosoma mansoni	tyrosine kinase	0.0435	0.7185	1
Schistosoma mansoni	shc transforming protein	0.0287	0.4151	0.4856
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0287	0.4151	0.5016
Loa Loa (eye worm)	TK/FER protein kinase	0.0435	0.7185	0.677
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Echinococcus multilocularis	tyrosine protein kinase shark	0.0435	0.7185	1
Trichomonas vaginalis	AGC family protein kinase	0.0222	0.2813	1
Schistosoma mansoni	tensin-related	0.0287	0.4151	0.4856
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Mycobacterium ulcerans	nitrate/nitrite response regulator protein NarL	0.0159	0.151	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0149	0.1318	0.0254
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0435	0.7185	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.3351	0.2369
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0148	0.1286	0.036
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0435	0.7185	0.9949
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Schistosoma mansoni	serine/threonine-protein kinase	0.0152	0.1378	0.0155
Plasmodium falciparum	protein kinase, putative	0.0148	0.1286	0.8572
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	protein kinase	0.0148	0.1286	0.036
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0148	0.1286	0.0362
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Loa Loa (eye worm)	TK/FER protein kinase	0.0435	0.7185	0.677
Echinococcus granulosus	kinase suppressor of Ras 1	0.0148	0.1286	0.036
Trichomonas vaginalis	AGC family protein kinase	0.0222	0.2813	1
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0148	0.1286	0.0362
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Schistosoma mansoni	protein kinase	0.0149	0.1318	0.0054
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0287	0.4151	0.4856
Trichomonas vaginalis	CAMK family protein kinase	0.0148	0.1286	0.4573
Plasmodium falciparum	tyrosine kinase-like protein	0.0148	0.1286	0.8572
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Brugia malayi	SH2 domain containing protein	0.0287	0.4151	0.3287
Onchocerca volvulus		0.0435	0.7185	1
Brugia malayi	Variant SH3 domain containing protein	0.0287	0.4151	0.3287
Echinococcus granulosus	SH2 domain containing protein 7	0.0287	0.4151	0.5016
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0435	0.7185	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0148	0.1286	0.036
Echinococcus multilocularis	signal transduction protein lnk realted	0.0287	0.4151	0.5042
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Loa Loa (eye worm)	TK/ABL protein kinase	0.0435	0.7185	0.677
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Leishmania major	protein kinase, putative	0.0149	0.1318	1
Trichomonas vaginalis	AGC family protein kinase	0.0222	0.2813	1
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Loa Loa (eye worm)	SH2 domain-containing protein	0.0287	0.4151	0.3287
Echinococcus granulosus	tyrosine kinase	0.0435	0.7185	0.9949
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	epidermal growth factor receptor	0.0148	0.1286	0.036
Entamoeba histolytica	serine/threonine kinase, putative	0.0148	0.1286	0.0312
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0287	0.4151	0.5042
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	ephrin type A receptor 4 A	0.0148	0.1286	0.036
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0287	0.4151	0.4856
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0435	0.7185	0.9949
Schistosoma mansoni	hypothetical protein	0.0287	0.4151	0.4856
Echinococcus granulosus	tyrosine protein kinase pr2	0.0148	0.1286	0.036
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0287	0.4151	0.5016
Plasmodium vivax	protein kinase, putative	0.0148	0.1286	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0287	0.4151	0.3287
Echinococcus multilocularis	activated cdc42 kinase 1	0.0148	0.1286	0.0362
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0287	0.4151	0.4856
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0148	0.1286	0.0362
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0287	0.4151	0.4856
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0435	0.7185	0.9949
Schistosoma mansoni	suppressor of cytokine signaling	0.0287	0.4151	0.4856
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0287	0.4151	0.5016
Entamoeba histolytica	hypothetical protein	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0152	0.1378	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0148	0.1286	0.036
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.1286	0.4573
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	N chimaerin	0.0287	0.4151	0.5016
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0287	0.4151	0.3287
Echinococcus granulosus	tumor protein p63	0.0366	0.5769	0.7646
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.1286	0.4573
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Brugia malayi	SH2 domain containing protein	0.0287	0.4151	0.3287
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Echinococcus granulosus	receptor type guanylyl cyclase	0.0148	0.1286	0.036
Echinococcus multilocularis	c src tyrosine kinase	0.0435	0.7185	1
Echinococcus multilocularis	tumor protein p63	0.0366	0.5769	0.7686
Schistosoma mansoni	suppressor of cytokine signaling	0.0287	0.4151	0.4856
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0149	0.1318	0.0207
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Trichomonas vaginalis	AGC family protein kinase	0.0222	0.2813	1
Loa Loa (eye worm)	hypothetical protein	0.0301	0.4432	0.361
Echinococcus multilocularis	N chimaerin	0.0287	0.4151	0.5042
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Schistosoma mansoni	tensin	0.0287	0.4151	0.4856
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0148	0.1286	0.0362
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0435	0.7185	1
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Loa Loa (eye worm)	SRC-1	0.0435	0.7185	0.677
Mycobacterium ulcerans	two component transcriptional regulatory protein DevR	0.0159	0.151	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0148	0.1286	0.0362
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0266	0.3715	0.433
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Loa Loa (eye worm)	SH2 domain-containing protein	0.0287	0.4151	0.3287
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	protein kinase, putative	0.0222	0.2813	0.2819
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Echinococcus multilocularis	rac serine:threonine kinase	0.0152	0.1378	0.0512
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Echinococcus granulosus	signal transduction protein lnk realted	0.0287	0.4151	0.5016
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Mycobacterium ulcerans	putative regulatory protein	0.0159	0.151	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0287	0.4151	0.3287
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0148	0.1286	0.036
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Entamoeba histolytica	tyrosin kinase, putative	0.0148	0.1286	0.0312
Mycobacterium ulcerans	two component transcriptional regulator	0.0159	0.151	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Schistosoma mansoni	nck2/grb4	0.0287	0.4151	0.4856
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0148	0.1286	0.036
Entamoeba histolytica	SH2 domain containing protein	0.0287	0.4151	0.5016
Entamoeba histolytica	hypothetical protein	0.0155	0.1428	0.0545
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0148	0.1286	0.0362
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0148	0.1286	0.036
Brugia malayi	Protein kinase domain containing protein	0.0435	0.7185	0.677
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0148	0.1286	0.036
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0148	0.1286	0.036
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0435	0.7185	1
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus multilocularis	SHC transforming protein 3	0.0287	0.4151	0.5042
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0435	0.7185	0.9949
Entamoeba histolytica	protein kinase, putative	0.0148	0.1286	0.0312
Echinococcus granulosus	growth factor receptor bound protein 2	0.0287	0.4151	0.5016
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	tyrosine protein kinase Srms	0.0435	0.7185	0.9949
Entamoeba histolytica	hypothetical protein	0.0148	0.1286	0.0312
Echinococcus multilocularis	NCK adaptor protein	0.0287	0.4151	0.5042
Schistosoma mansoni	tyrosine kinase	0.0435	0.7185	1
Brugia malayi	Protein kinase domain containing protein	0.0435	0.7185	0.677
Echinococcus granulosus	tyrosine kinase	0.0435	0.7185	0.9949
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0148	0.1286	0.036
Mycobacterium tuberculosis	Possible transcriptional regulatory protein	0.0159	0.151	0.5
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0222	0.2813	0.1752
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Entamoeba histolytica	hypothetical protein	0.0155	0.1428	0.0545
Entamoeba histolytica	tyrosin kinase, putative	0.0148	0.1286	0.0312
Onchocerca volvulus		0.0435	0.7185	1
Schistosoma mansoni	tyrosine kinase	0.0435	0.7185	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0148	0.1286	0.0362
Echinococcus granulosus	tyrosine kinase	0.0148	0.1286	0.036
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Trichomonas vaginalis	protein kinase atn1, putative	0.0148	0.1286	0.4573
Loa Loa (eye worm)	TK/FER protein kinase	0.0435	0.7185	0.677
Entamoeba histolytica	protein kinase domain containing protein	0.0149	0.1318	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0287	0.4151	0.3287
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0148	0.1286	0.0362
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0435	0.7185	1
Entamoeba histolytica	protein kinase, putative	0.0208	0.2531	0.2357
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.1286	0.4573
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0435	0.7185	0.9949
Entamoeba histolytica	hypothetical protein	0.0148	0.1286	0.0312
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0435	0.7185	1
Entamoeba histolytica	protein kinase, putative	0.0289	0.4182	0.5068
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Echinococcus granulosus	SH2 motif	0.0287	0.4151	0.5016
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0287	0.4151	0.5042
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0289	0.4182	0.5068
Entamoeba histolytica	receptor protein kinase, putative	0.0148	0.1286	0.0312
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Onchocerca volvulus		0.0435	0.7185	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0435	0.7185	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0148	0.1286	0.0362
Onchocerca volvulus		0.0287	0.4151	0.4856
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Echinococcus multilocularis	tensin	0.0287	0.4151	0.5042
Brugia malayi	p70 ribosomal S6 kinase beta	0.0208	0.2531	0.1429
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0148	0.1286	0.036
Loa Loa (eye worm)	TK/FER protein kinase	0.0435	0.7185	0.677
Entamoeba histolytica	receptor protein kinase, putative	0.0148	0.1286	0.0312
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0148	0.1286	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0287	0.4151	0.3287
Trichomonas vaginalis	conserved hypothetical protein	0.0148	0.1286	0.4573
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0148	0.1286	0.0312
Echinococcus multilocularis	SH2 domain containing protein 7	0.0287	0.4151	0.5042
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Entamoeba histolytica	hypothetical protein	0.0148	0.1286	0.0312
Trypanosoma cruzi	protein kinase, putative	0.0148	0.1286	0.6744
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0435	0.7185	0.9949
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0435	0.7185	0.9949
Echinococcus granulosus	expressed conserved protein	0.0287	0.4151	0.5016
Echinococcus granulosus	tyrosine protein kinase	0.0148	0.1286	0.036
Trichomonas vaginalis	TKL family protein kinase	0.0148	0.1286	0.4573
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0435	0.7185	1
Echinococcus multilocularis	SH2 motif	0.0287	0.4151	0.5042
Schistosoma mansoni	protein kinase	0.0149	0.1318	0.0054
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0148	0.1286	1
Brugia malayi	RhoGAP domain containing protein	0.0287	0.4151	0.3287
Entamoeba histolytica	protein kinase domain containing protein	0.0148	0.1286	0.0312
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	serine/threonine kinase, putative	0.0148	0.1286	0.0312
Echinococcus multilocularis	tyrosine kinase	0.0148	0.1286	0.0362
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0148	0.1286	0.0362
Brugia malayi	SH2 domain containing protein	0.0287	0.4151	0.3287
Entamoeba histolytica	tyrosine kinase, putative	0.0148	0.1286	0.0312
Entamoeba histolytica	hypothetical protein	0.0155	0.1428	0.0545
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0287	0.4151	0.5042

Activities

Activity type	Activity value	Assay description	Source	Reference
Concentration (functional)	= 2 uM	Concentration required for half-maximal activation of LuxR protein was determined by following the luminescence of the biosensor strain	ChEMBL.	11934577
IC50 (functional)	= 2 uM	Tested for the ability to interfere with the induction of luminescence by N-3-oxohexanoyl-L-homoserine lactone in the Vibrio fischeri QS system	ChEMBL.	15380216

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL15678

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 15857