Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0397 | 0.2678 | 1 |
Giardia lamblia | Kinase, TTK | 0.0397 | 0.2678 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0247 | 0.1556 | 0.5019 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0397 | 0.2678 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0247 | 0.1556 | 0.1556 |
Leishmania major | protein kinase, putative | 0.0247 | 0.1556 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0247 | 0.1556 | 0.5019 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0397 | 0.2678 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0247 | 0.1556 | 0.1556 |
Trypanosoma brucei | aurora B kinase | 0.0247 | 0.1556 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0247 | 0.1556 | 0.5 |
Toxoplasma gondii | aurora kinase | 0.0247 | 0.1556 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0247 | 0.1556 | 0.5019 |
Brugia malayi | serine/threonine kinase 12 | 0.0247 | 0.1556 | 0.1556 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0247 | 0.1556 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0247 | 0.1556 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0425 | 0.0425 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0247 | 0.1556 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0247 | 0.1556 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0397 | 0.2678 | 0.2678 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0425 | 0.0425 |
Trichomonas vaginalis | AGC family protein kinase | 0.0247 | 0.1556 | 0.5019 |
Loa Loa (eye worm) | AUR protein kinase | 0.0247 | 0.1556 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.1373 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | TTK protein kinase | 0.0397 | 0.2678 | 0.2678 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0247 | 0.1556 | 0.5 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0247 | 0.1556 | 0.1556 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0397 | 0.2678 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0247 | 0.1556 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0247 | 0.1556 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0397 | 0.2678 | 1 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0397 | 0.2678 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0247 | 0.1556 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0247 | 0.1556 | 0.1556 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0247 | 0.1556 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.