Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | sentrin-specific protease 1, putative | 0.0045 | 0.6325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0045 | 0.6325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.6325 | 0.6325 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5371 | 0.5371 |
Echinococcus multilocularis | sentrin specific protease 1 | 0.0045 | 0.6325 | 1 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0045 | 0.6325 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5371 | 0.8492 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0045 | 0.6325 | 0.5 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0045 | 0.6325 | 1 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0045 | 0.6325 | 0.6325 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5371 | 0.5371 |
Plasmodium falciparum | sentrin-specific protease 1 | 0.0045 | 0.6325 | 0.5 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0045 | 0.6325 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Echinococcus granulosus | sentrin specific protease 1 | 0.0045 | 0.6325 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.