Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0083 | 0.2121 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0266 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0266 | 0.0323 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0437 | 0.053 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0254 | 0.8249 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0266 | 0.0303 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0608 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0266 | 0.0323 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0266 | 0.0323 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0608 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0083 | 0.2121 | 0.8342 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0266 | 0.0323 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0266 | 0.0323 |
Mycobacterium tuberculosis | Probable reductase | 0.0083 | 0.2121 | 0.8342 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0266 | 0.0323 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0437 | 0.053 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0254 | 0.8249 | 0.9387 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0032 | 0.0266 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0032 | 0.0266 | 0.0303 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0032 | 0.0266 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0608 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0271 | 0.8857 | 0.8826 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0608 | 0.0397 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.2455 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0083 | 0.2121 | 0.8342 |
Leishmania major | trypanothione reductase | 0.0037 | 0.0437 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.0455 | 0.022 |
Brugia malayi | nuclear hormone receptor | 0.0032 | 0.0266 | 0.0303 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0266 | 0.0323 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0266 | 0.0303 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0437 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.2455 | 1 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0608 | 0.0691 |
Brugia malayi | ecdysteroid receptor | 0.0032 | 0.0266 | 0.0303 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0032 | 0.0266 | 0.0303 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0266 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0266 | 0.0323 |
Onchocerca volvulus | 0.0032 | 0.0266 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0266 | 0.0303 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.2455 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0266 | 0.0303 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0266 | 0.0303 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0266 | 0.0323 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0608 | 0.0351 |
Schistosoma mansoni | thyroid hormone receptor | 0.0302 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0266 | 0.0323 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0269 | 0.8788 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0266 | 0.0303 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0271 | 0.8857 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0437 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0608 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0266 | 0.0303 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0032 | 0.0266 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0266 | 0.0323 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0083 | 0.2121 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0266 | 0.0323 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0437 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0266 | 0.0323 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0437 | 0.0498 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0266 | 0.0303 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0271 | 0.8857 | 0.8826 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.0437 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0608 | 0.0351 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0032 | 0.0266 | 0.0323 |
Schistosoma mansoni | thyroid hormone receptor | 0.0302 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.2455 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0266 | 0.0303 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0032 | 0.0266 | 0.0303 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0254 | 0.8249 | 0.9387 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0608 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0032 | 0.0266 | 0.0303 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0266 | 0.0303 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0437 | 0.0498 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0032 | 0.0266 | 0.0323 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.0455 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.8184 | 0.9922 |
Brugia malayi | steroid hormone receptor | 0.0032 | 0.0266 | 0.0303 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0083 | 0.2121 | 0.8342 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0437 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0266 | 0.0303 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 10 mg kg-1 | Tested for the protection against glutamic acid-evoked convulsions in rats by intraperitoneal administration | ChEMBL. | 10425092 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.