Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0047 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0299 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 1 | 1 |
Echinococcus multilocularis | Transglutaminase | 0.0299 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0299 | 1 | 0.5 |
Mycobacterium tuberculosis | Long conserved protein | 0.0299 | 1 | 0.5 |
Onchocerca volvulus | 0.0299 | 1 | 1 | |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4183 | 0.4156 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0047 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0299 | 1 | 0.5 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0299 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0238 | 0.7722 | 0.7711 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0299 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0299 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6457 | 0.644 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0238 | 0.7722 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4183 | 0.5389 |
Echinococcus multilocularis | geminin | 0.0205 | 0.6457 | 0.644 |
Giardia lamblia | Hypothetical protein | 0.0299 | 1 | 0.5 |
Echinococcus granulosus | Transglutaminase | 0.0299 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0299 | 1 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0047 | 0.0047 |
Onchocerca volvulus | 0.0271 | 0.896 | 0.8955 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4183 | 0.5389 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0299 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.6457 | 0.644 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0299 | 1 | 0.5 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0299 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.6457 | 0.6457 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0299 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0299 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.