Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Phosphoglycerate kinase | 0.0179 | 0.1704 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0446 | 0.5733 | 1 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0179 | 0.1704 | 0.5 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0179 | 0.1704 | 0.1704 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0179 | 0.1704 | 0.2893 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.073 | 1 | 1 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0179 | 0.1704 | 0.2958 |
Brugia malayi | beta-lactamase family protein | 0.007 | 0.0064 | 0.0064 |
Brugia malayi | beta-lactamase | 0.007 | 0.0064 | 0.0064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0064 | 0.0064 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0179 | 0.1704 | 0.1704 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0438 | 0.5609 | 1 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0179 | 0.1704 | 1 |
Treponema pallidum | phosphoglycerate kinase | 0.0179 | 0.1704 | 0.5 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0179 | 0.1704 | 0.2958 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0179 | 0.1704 | 1 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0179 | 0.1704 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0438 | 0.5609 | 1 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0179 | 0.1704 | 1 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0179 | 0.1704 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.073 | 1 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0438 | 0.5609 | 1 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0179 | 0.1704 | 0.1704 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0179 | 0.1704 | 0.1704 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0179 | 0.1704 | 0.1704 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0438 | 0.5609 | 0.5609 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0064 | 0.0064 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0179 | 0.1704 | 0.2958 |
Loa Loa (eye worm) | hypothetical protein | 0.0373 | 0.4628 | 0.4593 |
Leishmania major | C-8 sterol isomerase-like protein | 0.073 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.073 | 1 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0438 | 0.5609 | 1 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0179 | 0.1704 | 0.1704 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0179 | 0.1704 | 0.2958 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0179 | 0.1704 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0438 | 0.5609 | 0.5581 |
Leishmania major | hypothetical protein, conserved | 0.007 | 0.0064 | 0.0064 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0179 | 0.1704 | 0.5 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0179 | 0.1704 | 1 |
Brugia malayi | Phosphoglycerate kinase | 0.0179 | 0.1704 | 0.1704 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0179 | 0.1704 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1704 | 0.1651 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0179 | 0.1704 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.007 | 0.0064 | 0.0064 |
Brugia malayi | beta-lactamase family protein | 0.007 | 0.0064 | 0.0064 |
Trypanosoma brucei | hypothetical protein, conserved | 0.007 | 0.0064 | 0.0064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.