Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0036 | 0.0022 | 0.0022 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.1015 | 0.2755 | 1 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0191 | 0.0453 | 0.5 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.1484 | 0.4065 | 0.7235 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.1577 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0191 | 0.0453 | 0.0453 |
Schistosoma mansoni | tyrosine kinase | 0.0042 | 0.0037 | 0.0037 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.1787 | 0.4913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3608 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0494 | 0.1301 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.1978 | 0.5446 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0036 | 0.0022 | 0.0022 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1978 | 0.5446 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0494 | 0.1301 | 0.1698 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0036 | 0.0022 | 0.0022 |
Schistosoma mansoni | camp/cgmp cyclic nucleotide phosphodiesterase | 0.0685 | 0.1833 | 0.1833 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.1577 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 0.1301 | 0.1301 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.1978 | 0.5446 | 1 |
Trypanosoma cruzi | cAMP-specific phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Schistosoma mansoni | adapter molecule crk | 0.0036 | 0.0022 | 0.0022 |
Schistosoma mansoni | tyrosine kinase | 0.0997 | 0.2705 | 0.2705 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0042 | 0.0037 | 0.0053 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.1484 | 0.4065 | 0.7235 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0322 | 0.082 | 0.1805 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0191 | 0.0453 | 0.0697 |
Echinococcus granulosus | c src tyrosine kinase | 0.0042 | 0.0037 | 0.0053 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Brugia malayi | Variant SH3 domain containing protein | 0.0036 | 0.0022 | 0.0022 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Trypanosoma cruzi | cyclic nucleotide phosphodiesterase | 0.0191 | 0.0453 | 0.0697 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Loa Loa (eye worm) | SRC-1 | 0.0042 | 0.0037 | 0.0037 |
Schistosoma mansoni | tyrosine kinase | 0.0042 | 0.0037 | 0.0037 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Toxoplasma gondii | hypothetical protein | 0.0494 | 0.1301 | 1 |
Toxoplasma gondii | GAF domain-containing protein | 0.0494 | 0.1301 | 1 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Schistosoma mansoni | camp-specific cyclic nucleotide phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Plasmodium vivax | hypothetical protein, conserved | 0.0494 | 0.1301 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0042 | 0.0037 | 0.0053 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.1978 | 0.5446 | 1 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0685 | 0.1833 | 0.4867 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0494 | 0.1301 | 0.1698 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0042 | 0.0037 | 0.0053 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0685 | 0.1833 | 0.1833 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0685 | 0.1833 | 0.4867 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Plasmodium falciparum | GAF domain-related protein, putative | 0.0494 | 0.1301 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0042 | 0.0037 | 0.0053 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.3608 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0494 | 0.1301 | 1 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0685 | 0.1833 | 0.6628 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Brugia malayi | Variant SH3 domain containing protein | 0.0036 | 0.0022 | 0.0022 |
Echinococcus multilocularis | dual 3',5' cyclic AMP and GMP phosphodiesterase | 0.0685 | 0.1833 | 0.6628 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0042 | 0.0037 | 0.0053 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0494 | 0.1301 | 0.1698 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0191 | 0.0453 | 0.0453 |
Schistosoma mansoni | DNA topoisomerase type I | 0.043 | 0.1122 | 0.1122 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Leishmania major | cAMP-specific phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0191 | 0.0453 | 0.0453 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Giardia lamblia | hypothetical protein | 0.0191 | 0.0453 | 0.5 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.043 | 0.1122 | 0.4024 |
Mycobacterium leprae | conserved hypothetical protein | 0.0494 | 0.1301 | 0.5 |
Echinococcus granulosus | high affinity cgmp specific 3' 5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Loa Loa (eye worm) | calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0036 | 0.0022 | 0.0022 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.0453 | 0.0453 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0685 | 0.1833 | 0.4867 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Trypanosoma brucei | GAF domain/TIP41-like family, putative | 0.1293 | 0.3533 | 1 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0036 | 0.0022 | 0.0022 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.043 | 0.1122 | 0.7888 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0042 | 0.0037 | 0.0037 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0685 | 0.1833 | 0.4867 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.043 | 0.1122 | 0.4024 |
Trypanosoma brucei | 3', 5'-cyclic nucleotide phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0042 | 0.0037 | 0.0053 |
Brugia malayi | DNA topoisomerase I | 0.043 | 0.1122 | 0.1122 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0042 | 0.0037 | 0.0053 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.1577 |
Brugia malayi | SRC-1 | 0.0042 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0022 | 0.0022 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Echinococcus multilocularis | high affinity cgmp specific 3' 5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0322 | 0.082 | 0.082 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.0191 | 0.0453 | 0.0697 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0042 | 0.0037 | 0.0037 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0042 | 0.0037 | 0.0053 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0042 | 0.0037 | 0.0053 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.043 | 0.1122 | 0.1122 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Plasmodium falciparum | topoisomerase I | 0.043 | 0.1122 | 0.7888 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0042 | 0.0037 | 0.0053 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0322 | 0.082 | 0.1805 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0042 | 0.0037 | 0.0053 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.1015 | 0.2755 | 1 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Trypanosoma brucei | 3', 5'-cyclic nucleotide phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.1787 | 0.4913 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0036 | 0.0022 | 0.0022 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1293 | 0.3533 | 0.6179 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.0453 | 0.0453 |
Leishmania major | cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 | 0.0191 | 0.0453 | 0.0697 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Leishmania major | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0322 | 0.082 | 0.082 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Echinococcus granulosus | dual 3'5' cyclic AMP and GMP phosphodiesterase | 0.0685 | 0.1833 | 0.6628 |
Schistosoma mansoni | nck2/grb4 | 0.0036 | 0.0022 | 0.0022 |
Schistosoma mansoni | tyrosine kinase | 0.0042 | 0.0037 | 0.0037 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.1577 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0042 | 0.0037 | 0.0053 |
Loa Loa (eye worm) | PDE1B protein | 0.0191 | 0.0453 | 0.0453 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.1293 | 0.3533 | 1 |
Trypanosoma brucei | cAMP-specific phosphodiesterase, putative | 0.0191 | 0.0453 | 0.0697 |
Schistosoma mansoni | tyrosine kinase | 0.0042 | 0.0037 | 0.0037 |
Giardia lamblia | Hypothetical protein | 0.0191 | 0.0453 | 0.5 |
Trypanosoma brucei | cAMP phosphodiesterase A, putative | 0.0191 | 0.0453 | 0.0697 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0042 | 0.0037 | 0.0053 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0685 | 0.1833 | 0.4867 |
Plasmodium vivax | topoisomerase I, putative | 0.043 | 0.1122 | 0.7888 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0191 | 0.0453 | 0.1577 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0042 | 0.0037 | 0.0053 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0494 | 0.1301 | 0.1698 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0322 | 0.082 | 0.1805 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.1293 | 0.3533 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.0191 | 0.0453 | 0.0453 |
Leishmania major | hypothetical protein, conserved | 0.1293 | 0.3533 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0685 | 0.1833 | 0.2765 |
Leishmania major | hypothetical protein, conserved | 0.0191 | 0.0453 | 0.0697 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0191 | 0.0453 | 0.0453 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0685 | 0.1833 | 0.6628 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.0453 | 0.0453 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.507 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.171 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.903 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.903 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.903 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.903 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.903 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.903 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.903 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.