Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | histone deacetylase 1, putative | 0.0227 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0227 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0131 | 0.5325 | 0.5325 |
Echinococcus granulosus | histone deacetylase 8 | 0.0065 | 0.2079 | 0.2079 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0065 | 0.2079 | 0.2079 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0065 | 0.2079 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0227 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0227 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0065 | 0.2079 | 0.2079 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0227 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0227 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0065 | 0.2079 | 0.2079 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0065 | 0.2079 | 0.2079 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0131 | 0.5325 | 0.5325 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0227 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0131 | 0.5325 | 0.5325 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0065 | 0.2079 | 0.2079 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0227 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0131 | 0.5325 | 0.5325 |
Schistosoma mansoni | histone deacetylase | 0.0227 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0065 | 0.2079 | 0.2079 |
Echinococcus granulosus | acetylcholinesterase | 0.0131 | 0.5325 | 0.5325 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0227 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0227 | 1 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0227 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0065 | 0.2079 | 0.2079 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.5325 | 0.5325 |
Echinococcus granulosus | acetylcholinesterase | 0.0131 | 0.5325 | 0.5325 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0022 | 0 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0227 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0227 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0131 | 0.5325 | 0.5325 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0131 | 0.5325 | 0.5325 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0065 | 0.2079 | 0.2079 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0065 | 0.2079 | 0.2079 |
Trypanosoma brucei | histone deacetylase 1 | 0.0227 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0065 | 0.2079 | 0.2079 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0131 | 0.5325 | 0.5325 |
Echinococcus granulosus | histone deacetylase 6 | 0.0065 | 0.2079 | 0.2079 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0227 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0065 | 0.2079 | 0.2079 |
Plasmodium falciparum | histone deacetylase 1 | 0.0227 | 1 | 1 |
Brugia malayi | histone deacetylase 11 | 0.0065 | 0.2079 | 0.2079 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.2079 | 0.2079 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0065 | 0.2079 | 0.2079 |
Echinococcus granulosus | histone deacetylase 3 | 0.0227 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0065 | 0.2079 | 0.2079 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.5325 | 0.5325 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0227 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0227 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0227 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0065 | 0.2079 | 0.2079 |
Echinococcus granulosus | histone deacetylase 6 | 0.0065 | 0.2079 | 0.2079 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0227 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0065 | 0.2079 | 0.2079 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0227 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0131 | 0.5325 | 0.5325 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0065 | 0.2079 | 0.2079 |
Echinococcus granulosus | histone deacetylase | 0.0065 | 0.2079 | 0.2079 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0227 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0227 | 1 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0227 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0227 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0227 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0065 | 0.2079 | 0.2079 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0065 | 0.2079 | 0.2079 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0227 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0131 | 0.5325 | 0.5325 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0065 | 0.209 | 0.0015 |
Giardia lamblia | Histone deacetylase | 0.0227 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Cytotoxicity against human A549 cells after 24 hrs by MTT assay | ChEMBL. | 22182926 |
IC50 (functional) | > 100 uM | Cytotoxicity against human HeLa cells after 24 hrs by MTT assay | ChEMBL. | 22182926 |
IC50 (functional) | > 100 uM | Cytotoxicity against human SW480 cells after 24 hrs by MTT assay | ChEMBL. | 22182926 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.