Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | malate dehydrogenase | 0.0485 | 0.2988 | 0.1194 |
Echinococcus granulosus | malate dehydrogenase | 0.0485 | 0.2988 | 0.1917 |
Brugia malayi | lactate dehydrogenase. | 0.0712 | 0.5296 | 0.3291 |
Onchocerca volvulus | 0.079 | 0.6085 | 0.5 | |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0391 | 0.2036 | 0.6089 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Mycobacterium leprae | PROBABLE MALATE DEHYDROGENASE MDH | 0.052 | 0.3345 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.0712 | 0.5296 | 0.4093 |
Loa Loa (eye worm) | hypothetical protein | 0.0712 | 0.5296 | 0.3291 |
Toxoplasma gondii | lactate dehydrogenase LDH1 | 0.0712 | 0.5296 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1176 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Wolbachia endosymbiont of Brugia malayi | malate dehydrogenase | 0.0712 | 0.5296 | 0.5 |
Echinococcus granulosus | malate dehydrogenase | 0.0485 | 0.2988 | 0.1917 |
Trypanosoma brucei | cytosolic malate dehydrogenase | 0.052 | 0.3345 | 1 |
Schistosoma mansoni | malate dehydrogenase | 0.052 | 0.3345 | 0.1643 |
Echinococcus multilocularis | cytosolic malate dehydrogenase | 0.052 | 0.3345 | 0.2329 |
Entamoeba histolytica | malate dehydrogenase, putative | 0.0712 | 0.5296 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Loa Loa (eye worm) | malate dehydrogenase | 0.052 | 0.3345 | 0.0509 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Leishmania major | cytosolic malate dehydrogenase | 0.052 | 0.3345 | 0.4014 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1176 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Plasmodium falciparum | malate dehydrogenase | 0.0712 | 0.5296 | 1 |
Leishmania major | glycosomal malate dehydrogenase | 0.0485 | 0.2988 | 0.2918 |
Schistosoma mansoni | alpha-glucosidase | 0.1176 | 1 | 1 |
Plasmodium vivax | malate dehydrogenase, putative | 0.0712 | 0.5296 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Chlamydia trachomatis | malate dehydrogenase | 0.052 | 0.3345 | 0.5 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0485 | 0.2988 | 0.7271 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Trypanosoma brucei | glycosomal malate dehydrogenase | 0.0485 | 0.2988 | 0.7271 |
Mycobacterium tuberculosis | Probable malate dehydrogenase Mdh | 0.052 | 0.3345 | 0.5 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0712 | 0.5296 | 0.4577 |
Toxoplasma gondii | malate dehydrogenase MDH | 0.0712 | 0.5296 | 0.5 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.0319 | 0.1308 | 0.3911 |
Leishmania major | malate dehydrogenase | 0.0485 | 0.2988 | 0.2918 |
Giardia lamblia | Malate dehydrogenase | 0.052 | 0.3345 | 0.5 |
Trypanosoma cruzi | cytosolic malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0712 | 0.5296 | 0.4577 |
Trypanosoma brucei | mitochondrial malate dehydrogenase | 0.0485 | 0.2988 | 0.7271 |
Leishmania major | mitochondrial malate dehydrogenase | 0.0485 | 0.2988 | 0.2918 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Echinococcus granulosus | cytosolic malate dehydrogenase | 0.052 | 0.3345 | 0.2329 |
Plasmodium vivax | lactate dehydrogenase | 0.0712 | 0.5296 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1176 | 1 | 1 |
Echinococcus granulosus | cytosolic malate dehydrogenase | 0.052 | 0.3345 | 0.2329 |
Schistosoma mansoni | alpha-glucosidase | 0.1176 | 1 | 1 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Echinococcus granulosus | L lactate dehydrogenase B chain | 0.0712 | 0.5296 | 0.4577 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Trypanosoma cruzi | mitochondrial malate dehydrogenase, putative | 0.0485 | 0.2988 | 0.7271 |
Mycobacterium ulcerans | malate dehydrogenase | 0.052 | 0.3345 | 0.5 |
Echinococcus granulosus | lactate dehydrogenase a | 0.0712 | 0.5296 | 0.4577 |
Echinococcus multilocularis | malate dehydrogenase | 0.0485 | 0.2988 | 0.1917 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0712 | 0.5296 | 0.4577 |
Trypanosoma cruzi | glycosomal malate dehydrogenase, putative | 0.0485 | 0.2988 | 0.7271 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Leishmania major | malate dehydrogenase, putative | 0.0712 | 0.5296 | 1 |
Echinococcus multilocularis | L lactate dehydrogenase B chain | 0.0712 | 0.5296 | 0.4577 |
Echinococcus multilocularis | cytosolic malate dehydrogenase | 0.052 | 0.3345 | 0.2329 |
Trypanosoma cruzi | malate dehydrogenase, putative | 0.0485 | 0.2988 | 0.7271 |
Echinococcus multilocularis | lactate dehydrogenase protein | 0.0712 | 0.5296 | 0.4577 |
Brugia malayi | Malate dehydrogenase, cytoplasmic | 0.052 | 0.3345 | 0.0509 |
Trichomonas vaginalis | malate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Echinococcus granulosus | lactate dehydrogenase protein | 0.0712 | 0.5296 | 0.4577 |
Schistosoma mansoni | malate dehydrogenase | 0.052 | 0.3345 | 0.1643 |
Echinococcus multilocularis | malate dehydrogenase | 0.0485 | 0.2988 | 0.1917 |
Trichomonas vaginalis | malate and lactate dehydrogenase, putative | 0.052 | 0.3345 | 1 |
Plasmodium falciparum | L-lactate dehydrogenase | 0.0712 | 0.5296 | 1 |
Toxoplasma gondii | lactate dehydrogenase LDH2 | 0.0712 | 0.5296 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1176 | 1 | 1 |
Echinococcus multilocularis | lactate dehydrogenase a | 0.0712 | 0.5296 | 0.4577 |
Schistosoma mansoni | L-lactate dehydrogenase | 0.0712 | 0.5296 | 0.4093 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.734 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.466 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.425 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.332 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.311 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.302 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.268 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.