Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0016 | 0.2335 | 0.1458 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0024 | 0.8021 | 0.8021 |
Schistosoma mansoni | lamin | 0.0027 | 1 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 0.8021 | 0.7795 |
Trichomonas vaginalis | chaperonin, putative | 0.0024 | 0.8021 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.8738 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 1 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 0.8021 | 0.7795 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.8738 | 1 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0024 | 0.8021 | 0.8021 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.8738 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.1026 | 0.1026 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.8738 | 0.8593 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.8738 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.8738 | 1 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0024 | 0.8021 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.8738 | 0.8738 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9646 | 0.9646 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0024 | 0.8021 | 0.5 |
Onchocerca volvulus | 0.0027 | 1 | 0.5 | |
Schistosoma mansoni | lamin | 0.0027 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.8738 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.8738 | 1 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0024 | 0.8021 | 0.8021 |
Echinococcus granulosus | lamin | 0.0027 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.8738 | 1 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0024 | 0.8021 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 0 % | Cytotoxicity against human KB cells assessed as growth inhibition at 10 '-6 M after 72 hrs by MTS assay | ChEMBL. | 22257529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.