Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2821 | 0.9225 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3056 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.3047 | 0.9972 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.3047 | 0.9972 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.2821 | 0.9225 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1387 | 0.4503 | 0.4512 |
Echinococcus granulosus | carbonic anhydrase | 0.1387 | 0.4503 | 0.4881 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0022 | 0.0007 | 0.0007 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2821 | 0.9225 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2821 | 0.9225 | 0.9251 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2821 | 0.9225 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2821 | 0.9225 | 0.9251 |
Loa Loa (eye worm) | hypothetical protein | 0.1387 | 0.4503 | 0.4862 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0022 | 0.0007 | 0.0007 |
Entamoeba histolytica | protein kinase, putative | 0.003 | 0.0034 | 0.0034 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1387 | 0.4503 | 0.4862 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1964 | 0.6403 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.3047 | 0.9972 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0032 | 0.004 | 0.004 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1387 | 0.4503 | 0.4862 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.3047 | 0.9972 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1387 | 0.4503 | 0.4512 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1387 | 0.4503 | 0.4862 |
Echinococcus multilocularis | carbonic anhydrase | 0.1387 | 0.4503 | 0.4881 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.002 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0032 | 0.004 | 0.004 |
Echinococcus granulosus | carbonic anhydrase | 0.1387 | 0.4503 | 0.4881 |
Echinococcus granulosus | carbonic anhydrase | 0.1387 | 0.4503 | 0.4881 |
Loa Loa (eye worm) | hypothetical protein | 0.1387 | 0.4503 | 0.4862 |
Brugia malayi | Protein kinase domain containing protein | 0.0032 | 0.004 | 0.0007 |
Toxoplasma gondii | hypothetical protein | 0.1387 | 0.4503 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3056 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1387 | 0.4503 | 0.4512 |
Schistosoma mansoni | hypothetical protein | 0.1387 | 0.4503 | 0.4512 |
Trypanosoma cruzi | Protein kinase B | 0.0022 | 0.0007 | 0.0007 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1956 | 0.6375 | 0.9902 |
Schistosoma mansoni | carbonic anhydrase | 0.1387 | 0.4503 | 0.4512 |
Loa Loa (eye worm) | hypothetical protein | 0.2001 | 0.6525 | 0.7062 |
Echinococcus multilocularis | carbonic anhydrase | 0.1387 | 0.4503 | 0.4881 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2821 | 0.9225 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0032 | 0.004 | 0.0007 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2821 | 0.9225 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1387 | 0.4503 | 0.4862 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0022 | 0.0007 | 0.0007 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1387 | 0.4503 | 0.4862 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0022 | 0.0007 | 0.0007 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2821 | 0.9225 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.1387 | 0.4503 | 0.4881 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2821 | 0.9225 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0022 | 0.0007 | 0.0007 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1387 | 0.4503 | 0.4862 |
Plasmodium falciparum | carbonic anhydrase | 0.1387 | 0.4503 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2821 | 0.9225 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.