Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.6198 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0674 | 0.0931 | 0.4985 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1245 | 0.1868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0674 | 0.0931 | 0.4985 |
Mycobacterium ulcerans | integral membrane transporter | 0.0197 | 0.0149 | 0.0149 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1245 | 0.1868 | 1 |
Mycobacterium ulcerans | transmembrane carbonic anhydrase, SulP | 0.0197 | 0.0149 | 0.0149 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0674 | 0.0931 | 0.4985 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0674 | 0.0931 | 0.4985 |
Plasmodium vivax | sulfate transporter, putative | 0.0197 | 0.0149 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0674 | 0.0931 | 0.4985 |
Mycobacterium ulcerans | transmembrane carbonic anhydrase, SulP | 0.0197 | 0.0149 | 0.0149 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0674 | 0.0931 | 0.4985 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1245 | 0.1868 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0674 | 0.0931 | 0.4985 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0299 | 0.0315 | 0.1689 |
Plasmodium falciparum | carbonic anhydrase | 0.0674 | 0.0931 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.1239 | 0.1858 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1245 | 0.1868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0674 | 0.0931 | 0.4985 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.173 | 0.2664 | 0.2801 |
Chlamydia trachomatis | sulfate transporter | 0.0197 | 0.0149 | 0.5 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.1431 | 0.2173 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1245 | 0.1868 | 1 |
Trypanosoma cruzi | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative | 0.0197 | 0.0149 | 0.0796 |
Echinococcus granulosus | carbonic anhydrase | 0.0674 | 0.0931 | 0.4985 |
Echinococcus granulosus | carbonic anhydrase | 0.0674 | 0.0931 | 0.4985 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0107 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1245 | 0.1868 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0674 | 0.0931 | 0.4985 |
Leishmania major | carbonic anhydrase-like protein | 0.1245 | 0.1868 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0674 | 0.0931 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1245 | 0.1868 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0674 | 0.0931 | 0.4985 |
Schistosoma mansoni | carbonic anhydrase | 0.0299 | 0.0315 | 0.1689 |
Echinococcus granulosus | carbonic anhydrase II | 0.1245 | 0.1868 | 1 |
Trypanosoma brucei | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative | 0.0197 | 0.0149 | 0.0796 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1245 | 0.1868 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.59 | 0.9509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0674 | 0.0931 | 0.4985 |
Echinococcus multilocularis | carbonic anhydrase | 0.0674 | 0.0931 | 0.4985 |
Trypanosoma cruzi | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative | 0.0197 | 0.0149 | 0.0796 |
Schistosoma mansoni | hypothetical protein | 0.0674 | 0.0931 | 0.4985 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0299 | 0.0315 | 0.1451 |
Schistosoma mansoni | carbonic anhydrase | 0.0674 | 0.0931 | 0.4985 |
Onchocerca volvulus | 0.1239 | 0.1858 | 0.5 | |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.1431 | 0.2173 | 0.2285 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0299 | 0.0315 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0674 | 0.0931 | 0.4985 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0674 | 0.0931 | 0.4985 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0674 | 0.0931 | 0.4985 |
Trichomonas vaginalis | conserved hypothetical protein | 0.6198 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1245 | 0.1868 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0674 | 0.0931 | 0.4985 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0299 | 0.0315 | 0.0315 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1245 | 0.1868 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.903 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.743 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.659 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.622 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.615 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.537 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.534 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.47 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.