Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase | 0.1603 | 0.3324 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0475 | 0 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1603 | 0.3324 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.1057 | 0.1715 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0821 | 0.102 | 0.031 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0475 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3867 | 1 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.1057 | 0.1715 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.3086 | 0.7696 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3867 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.153 | 0.311 | 0.3344 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1603 | 0.3324 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1603 | 0.3324 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.1426 | 0.2805 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0648 | 0.051 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.084 | 0.1076 | 0.3238 |
Loa Loa (eye worm) | integrin beta-2 | 0.1426 | 0.2805 | 1 |
Onchocerca volvulus | 0.0648 | 0.051 | 0.5 | |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0475 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.