Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase II | 0.0165 | 0.0809 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.134 | 1 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1069 | 0.7882 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0061 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0165 | 0.0809 | 0.2093 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0165 | 0.0809 | 0.2093 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0165 | 0.0809 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0555 | 0.3864 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0555 | 0.3864 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0165 | 0.0809 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0061 | 0 | 0.5 |
Onchocerca volvulus | 0.0225 | 0.1278 | 0.5 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0165 | 0.0809 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0165 | 0.0809 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0225 | 0.1278 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0284 | 0.1746 | 0.031 |
Echinococcus granulosus | carbonic anhydrase II | 0.0165 | 0.0809 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0165 | 0.0809 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0165 | 0.0809 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.053 | 0.3668 | 0.3344 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0165 | 0.0809 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.134 | 1 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0555 | 0.3864 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0555 | 0.3864 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 43 % | Cytotoxicity against human HEY cells at 10 uM after 72 hrs by MTT assay | ChEMBL. | 22209417 |
Activity (functional) | = 50 % | Cytotoxicity against p53-positive human HCT116 cells at 10 uM after 72 hrs by MTT assay | ChEMBL. | 22209417 |
Activity (functional) | = 63 % | Cytotoxicity against p53-deficient human HCT116 cells at 10 uM after 72 hrs by MTT assay | ChEMBL. | 22209417 |
IC50 (functional) | = 8 uM | Cytotoxicity against p53-positive human HCT116 cells after 72 hrs by MTT assay | ChEMBL. | 22209417 |
IC50 (functional) | > 10 uM | Cytotoxicity against p53-deficient human HCT116 cells after 72 hrs by MTT assay | ChEMBL. | 22209417 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22209417 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.