Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Mycobacterium ulcerans | epoxide hydrolase EphA | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0158 | 0.0987 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0158 | 0.0987 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.025 | 0.1714 | 0.0629 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0197 | 0.1297 | 0.1297 |
Toxoplasma gondii | hypothetical protein | 0.0059 | 0.0194 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0158 | 0.0987 | 0.2093 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0535 | 0.3983 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0158 | 0.0987 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0535 | 0.3983 | 0.3983 |
Echinococcus granulosus | carbonic anhydrase II | 0.0158 | 0.0987 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0059 | 0.0194 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0158 | 0.0987 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.103 | 0.7923 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0158 | 0.0987 | 0.2093 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1291 | 1 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0216 | 0.1447 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0535 | 0.3983 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0535 | 0.3983 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0535 | 0.3983 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1291 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0158 | 0.0987 | 1 |
Plasmodium vivax | sulfate transporter, putative | 0.0034 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0158 | 0.0987 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0158 | 0.0987 | 1 |
Onchocerca volvulus | 0.0216 | 0.1447 | 0.5 | |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0274 | 0.1906 | 0.0919 |
Chlamydia trachomatis | sulfate transporter | 0.0034 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0158 | 0.0987 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0511 | 0.379 | 0.3763 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 78 nM | Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay | ChEMBL. | 22079754 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.