Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | epoxide hydrolase EphA | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carbonic anhydrase | 0.1022 | 0.3634 | 0.3634 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2466 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0303 | 0.0464 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1022 | 0.3634 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1022 | 0.3634 | 1 |
Onchocerca volvulus | 0.0413 | 0.0951 | 0.5 | |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0523 | 0.1437 | 0.1841 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0303 | 0.0464 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0975 | 0.343 | 0.4396 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0303 | 0.0464 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0303 | 0.0464 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0303 | 0.0464 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.1022 | 0.3634 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1022 | 0.3634 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0303 | 0.0464 | 0.5 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0477 | 0.1233 | 0.158 |
Echinococcus granulosus | carbonic anhydrase II | 0.0303 | 0.0464 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2466 | 1 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0413 | 0.0951 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1967 | 0.7803 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0303 | 0.0464 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0303 | 0.0464 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 450 nM | Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay | ChEMBL. | 22079754 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.