Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | sodium/hydrogen exchanger 3 family protein | 0.0191 | 0 | 0.5 |
Schistosoma mansoni | sodium/hydrogen exchanger 2 (nhe2) | 0.0191 | 0 | 0.5 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0191 | 0 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0191 | 0 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0191 | 0 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1033 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0191 | 0 | 0.5 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.0191 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1033 | 1 | 0.5 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0191 | 0 | 0.5 |
Schistosoma mansoni | sodium/hydrogen exchanger | 0.0191 | 0 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0191 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1033 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0191 | 0 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1033 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0191 | 0 | 0.5 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0191 | 0 | 0.5 |
Loa Loa (eye worm) | NHE-3 | 0.0191 | 0 | 0.5 |
Loa Loa (eye worm) | sodium/hydrogen exchanger | 0.0191 | 0 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1033 | 1 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0191 | 0 | 0.5 |
Brugia malayi | sodium/hydrogen exchanger 3 family protein | 0.0191 | 0 | 0.5 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0191 | 0 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0191 | 0 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0191 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.663 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.399 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.911 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.69 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.556 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.472 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.421 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.176 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.