Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 14 (membrane-inserted) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 12 (macrophage elastase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 12 (macrophage elastase) | 470 aa | 467 aa | 32.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0368 | 0.5668 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0257 | 0.2211 | 0.3266 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0368 | 0.5668 | 0.5022 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0508 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0368 | 0.5668 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0227 | 0.1299 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0368 | 0.5668 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0368 | 0.5668 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0368 | 0.5668 | 0.5022 |
Onchocerca volvulus | Matrilysin homolog | 0.0344 | 0.4908 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0368 | 0.5668 | 1 |
Giardia lamblia | Hypothetical protein | 0.0326 | 0.437 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0203 | 0.0534 | 0.0941 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0227 | 0.1299 | 0.149 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0368 | 0.5668 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0368 | 0.5668 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0368 | 0.5668 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0368 | 0.5668 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.5668 | 1 |
Brugia malayi | Matrixin family protein | 0.0367 | 0.5626 | 0.9903 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0326 | 0.437 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0368 | 0.5668 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0368 | 0.5668 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0368 | 0.5668 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0368 | 0.5668 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0227 | 0.1299 | 0.2291 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0368 | 0.5668 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0368 | 0.5668 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0368 | 0.5668 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0368 | 0.5668 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0368 | 0.5668 | 0.5022 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0368 | 0.5668 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0367 | 0.5626 | 0.9918 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0368 | 0.5668 | 0.5022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5 | Inhibition of MMP14 using Mca-Pro-cyclohexyl-Ala-Gly-Nva-His-Ala- Dap(Dnp)-NH2 as substrate by fluorometric analysis | ChEMBL. | 22153941 |
IC50 (binding) | > 5 | Inhibition of MMP12 using Mca-Pro-cyclohexyl-Ala-Gly-Nva-His-Ala- Dap(Dnp)-NH2 as substrate by fluorometric analysis | ChEMBL. | 22153941 |
IC50 (binding) | > 5 | Inhibition of MMP9 using Mca-Pro-cyclohexyl-Ala-Gly-Nva-His-Ala- Dap(Dnp)-NH2 as substrate by fluorometric analysis | ChEMBL. | 22153941 |
IC50 (binding) | = 5.3 | Inhibition of MMP2 using Mca-Pro-cyclohexyl-Ala-Gly-Nva-His-Ala- Dap(Dnp)-NH2 as substrate by fluorometric analysis | ChEMBL. | 22153941 |
IC50 (binding) | = 7.4 | Inhibition of recombinant human MMP13 using Mca-Pro-cyclohexyl-Ala-Gly-Nva-His-Ala- Dap(Dnp)-NH2 as substrate by fluorometric analysis | ChEMBL. | 22153941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.