Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Histone deacetylase 1 | 0.029 | 0.0918 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0109 | 0.0232 | 0.2531 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0109 | 0.0232 | 0.2531 |
Echinococcus granulosus | histone deacetylase 6 | 0.0109 | 0.0232 | 0.0959 |
Echinococcus granulosus | histone deacetylase 7 | 0.0109 | 0.0232 | 0.0959 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.0274 | 0.0046 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.029 | 0.0918 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.029 | 0.0918 | 0.5 |
Trypanosoma brucei | histone deacetylase 2 | 0.0109 | 0.0232 | 0.2531 |
Echinococcus multilocularis | histone deacetylase 3 | 0.029 | 0.0918 | 0.3791 |
Echinococcus granulosus | histone deacetylase | 0.0109 | 0.0232 | 0.0959 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.029 | 0.0918 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0109 | 0.0232 | 0.2531 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.0228 | 0.0228 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.029 | 0.0918 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.0228 | 0.0228 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0688 | 0.2423 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0109 | 0.0232 | 0.2531 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.0274 | 0.0274 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.029 | 0.0918 | 1 |
Leishmania major | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Trypanosoma brucei | histone deacetylase 4 | 0.0109 | 0.0232 | 0.2531 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.0918 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0109 | 0.0232 | 0.2531 |
Echinococcus granulosus | histone deacetylase 3 | 0.029 | 0.0918 | 0.3791 |
Echinococcus multilocularis | histone deacetylase | 0.0109 | 0.0232 | 0.0959 |
Trichomonas vaginalis | histone deacetylase, putative | 0.029 | 0.0918 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Plasmodium falciparum | histone deacetylase 1 | 0.029 | 0.0918 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0109 | 0.0232 | 0.2531 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.0228 | 0.0228 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0109 | 0.0232 | 0.0959 |
Echinococcus granulosus | histone deacetylase 6 | 0.0109 | 0.0232 | 0.0959 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.029 | 0.0918 | 0.5 |
Entamoeba histolytica | histone deacetylase, putative | 0.029 | 0.0918 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.029 | 0.0918 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.0274 | 0.0274 |
Brugia malayi | Histone deacetylase family protein | 0.0109 | 0.0232 | 0.2531 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.029 | 0.0918 | 1 |
Mycobacterium tuberculosis | Transcriptional regulatory repressor protein (TetR-family) EthR | 0.2694 | 1 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0109 | 0.0232 | 0.0959 |
Echinococcus granulosus | histone deacetylase 6 | 0.0109 | 0.0232 | 0.0959 |
Giardia lamblia | Histone deacetylase | 0.029 | 0.0918 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.0689 | 0.0689 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.029 | 0.0918 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Plasmodium vivax | histone deacetylase 1, putative | 0.029 | 0.0918 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.029 | 0.0918 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0109 | 0.0232 | 0.0959 |
Trichomonas vaginalis | histone deacetylase, putative | 0.029 | 0.0918 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0232 | 0.2531 |
Trichomonas vaginalis | histone deacetylase, putative | 0.029 | 0.0918 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0688 | 0.2423 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0109 | 0.0232 | 0.2531 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0109 | 0.0232 | 0.0959 |
Loa Loa (eye worm) | histone deacetylase | 0.0109 | 0.0232 | 0.2531 |
Echinococcus multilocularis | histone deacetylase 1 | 0.029 | 0.0918 | 0.3791 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0109 | 0.0232 | 0.2531 |
Plasmodium falciparum | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Trypanosoma brucei | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Schistosoma mansoni | histone deacetylase | 0.029 | 0.0918 | 0.3132 |
Mycobacterium ulcerans | TetR family transcriptional regulator | 0.2694 | 1 | 0.5 |
Mycobacterium ulcerans | transcriptional regulator | 0.2694 | 1 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Trichomonas vaginalis | histone deacetylase, putative | 0.029 | 0.0918 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.029 | 0.0918 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0109 | 0.0232 | 0.0959 |
Schistosoma mansoni | histone deacetylase | 0.029 | 0.0918 | 0.3132 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.029 | 0.0918 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.029 | 0.0918 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0109 | 0.0232 | 0.2531 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0688 | 0.2423 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.029 | 0.0918 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0109 | 0.0232 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.0228 | 0.0228 |
Mycobacterium ulcerans | AcrR family transcriptional regulator | 0.2694 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.029 | 0.0918 | 0.3791 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.0228 | 0.0228 |
Leishmania major | histone deacetylase, putative | 0.029 | 0.0918 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.0274 | 0.0274 |
Echinococcus granulosus | histone deacetylase 8 | 0.0109 | 0.0232 | 0.0959 |
Trypanosoma brucei | histone deacetylase 3 | 0.0109 | 0.0232 | 0.2531 |
Brugia malayi | histone deacetylase 11 | 0.0109 | 0.0232 | 0.2531 |
Leishmania major | histone deacetylase, putative | 0.029 | 0.0918 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.0228 | 0.0228 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.767 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.751 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.734 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.717 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.697 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.