Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | diflavin oxidoreductase | 0.0045 | 0.0129 | 0.0521 |
Echinococcus multilocularis | thymidine phosphorylase | 0.2727 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0019 | 0.0378 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0091 | 0.0298 | 0.0298 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0023 | 0.0048 | 0.0947 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0.0091 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0143 | 0.2832 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.0298 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0035 | 0.0091 | 0.3033 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0091 | 0.0298 | 0.1207 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.0298 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.0298 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0081 | 0.026 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0035 | 0.0091 | 0.1792 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0019 | 0.0019 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0.0091 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0056 | 0.017 | 0.3358 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0091 | 0.0298 | 0.5908 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 0.0505 | 0.0505 |
Brugia malayi | flavodoxin family protein | 0.0091 | 0.0298 | 0.5908 |
Chlamydia trachomatis | sulfite reductase | 0.0056 | 0.017 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0.0091 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0148 | 0.0505 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0035 | 0.0091 | 0.1703 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0035 | 0.0091 | 0.1703 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0023 | 0.0048 | 0.0947 |
Giardia lamblia | Hypothetical protein | 0.0081 | 0.026 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0045 | 0.0129 | 1 |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0023 | 0.0048 | 0.1603 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.077 | 0.2795 | 0.2795 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0086 | 0.0347 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0019 | 0.0077 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0023 | 0.0048 | 0.1838 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0505 | 1 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0023 | 0.0048 | 0.1603 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0.0091 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0091 | 0.0298 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0091 | 0.0298 | 0.0298 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0091 | 0.3033 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0035 | 0.0091 | 0.3033 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0091 | 0.0298 | 1 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0023 | 0.0048 | 0.0048 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 0.0505 | 0.0505 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0019 | 0.0019 |
Brugia malayi | flavodoxin family protein | 0.0035 | 0.0091 | 0.1792 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0081 | 0.026 | 0.8717 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0019 | 0.0019 |
Treponema pallidum | flavodoxin | 0.0035 | 0.0091 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0045 | 0.0129 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0019 | 0.0378 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.0298 | 1 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0023 | 0.0048 | 0.1603 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0.0091 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0035 | 0.0091 | 0.3033 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0023 | 0.0048 | 0.0048 |
Leishmania major | p450 reductase, putative | 0.0091 | 0.0298 | 1 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0023 | 0.0048 | 0.1603 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0091 | 0.0298 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0298 | 0.5908 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.2727 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0019 | 0.0019 |
Leishmania major | cytochrome P450 reductase, putative | 0.0081 | 0.026 | 0.8717 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0035 | 0.0091 | 0.3033 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0091 | 0.0298 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0056 | 0.017 | 0.017 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0023 | 0.0048 | 0.0193 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.077 | 0.2795 | 0.2795 |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0023 | 0.0048 | 0.1603 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0035 | 0.0091 | 0.1703 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0091 | 0.0298 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0019 | 0.0378 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 0.0505 | 0.0505 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0682 | 0.2472 | 0.2472 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0019 | 0.0019 |
Echinococcus multilocularis | methionine synthase reductase | 0.0056 | 0.017 | 0.017 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0019 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0505 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.0298 | 1 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.2727 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0046 | 0.0131 | 0.0531 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0682 | 0.2472 | 0.2472 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0783 | 0.2846 | 0.2846 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0035 | 0.0091 | 0.1703 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0035 | 0.0091 | 0.3033 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0023 | 0.0048 | 0.0947 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0091 | 0.0298 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0019 | 0.0077 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0056 | 0.017 | 0.0686 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0035 | 0.0091 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0143 | 0.2832 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0019 | 0.0077 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0143 | 0.2832 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.0298 | 0.0298 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.077 | 0.2795 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0019 | 0.0019 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0091 | 0.0298 | 0.0298 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0023 | 0.0048 | 0.3714 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0143 | 0.2832 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0682 | 0.2472 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.0298 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0019 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0086 | 0.1696 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.0298 | 0.0298 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0023 | 0.0048 | 0.0193 |
Brugia malayi | FAD binding domain containing protein | 0.0091 | 0.0298 | 0.5908 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0023 | 0.0048 | 0.0193 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0091 | 0.3033 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0081 | 0.026 | 0.8473 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0086 | 0.1696 |
Brugia malayi | FAD binding domain containing protein | 0.0056 | 0.017 | 0.3358 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.3 uM | Inhibitory activity against human neuronal nitric oxide synthase (nNOS) isoenzyme. | ChEMBL. | 9667974 |
Ki (binding) | = 3.8 uM | Inhibitory activity against human endothelial nitric oxide synthase (eNOS) isoenzyme. | ChEMBL. | 9667974 |
Ki (binding) | = 17 uM | Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme. | ChEMBL. | 9667974 |
Selectivity (binding) | = 13 | Selectivity of the compound for human endothelial nitric oxide synthase (eNOS) and human neuronal selective nitric oxide synthase (nNOS) | ChEMBL. | 9667974 |
Selectivity (binding) | = 57 | Selectivity of the compound for human inducible nitric oxide synthase (iNOS) and human neuronal selective nitric oxide synthase (nNOS) | ChEMBL. | 9667974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.