ED50 (functional)
|
= 2.2 mg/ml
|
Antitrypanosomal activity against
|
ChEMBL.
|
18053726
|
ED50 (functional)
|
= 2.2 mg/ml
|
Antitrypanosomal activity against
|
ChEMBL.
|
18053726
|
ED50 (functional)
|
= 6.7 mg/ml
|
Antitrypanosomal activity against Trypanosoma cruzi
|
ChEMBL.
|
18053726
|
ED50 (functional)
|
= 6.7 mg/ml
|
Antitrypanosomal activity against Trypanosoma cruzi
|
ChEMBL.
|
18053726
|
ED50 (functional)
|
= 13.5 mg/ml
|
Antileishmanial activity against
|
ChEMBL.
|
18053726
|
ED50 (functional)
|
= 13.5 mg/ml
|
Antileishmanial activity against
|
ChEMBL.
|
18053726
|
ED50 (functional)
|
= 2.2 ug ml-1
|
Antiprotozoal activity of the compound against T. b. rhodesiense was determined
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 2.2 ug ml-1
|
Antiprotozoal activity of the compound against T. b. rhodesiense was determined
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 6.7 ug ml-1
|
Antiprotozoal activity of the compound against T. cruzi was determined
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 6.7 ug ml-1
|
Antiprotozoal activity of the compound against T. cruzi was determined
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 13.5 ug ml-1
|
Antiprotozoal activity of the compound against L. donovani was determined
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 13.5 ug ml-1
|
Antiprotozoal activity of the compound against L. donovani was determined
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 23 ug ml-1
|
Toxicity of the compound was determined in L. donovani infected KB cells
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 23 ug ml-1
|
Toxicity of the compound was determined in T. cruzi infected KB cells
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 23 ug ml-1
|
Toxicity of the compound was determined in T. b. rhodesiense infected KB cells
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 23 ug ml-1
|
Toxicity of the compound was determined in L. donovani infected KB cells
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 23 ug ml-1
|
Toxicity of the compound was determined in T. cruzi infected KB cells
|
ChEMBL.
|
14611847
|
ED50 (functional)
|
= 23 ug ml-1
|
Toxicity of the compound was determined in T. b. rhodesiense infected KB cells
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 0 %
|
Antiprotozoal activity of the compound against L. donovani at a dose of 3 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
0 %
|
Antiprotozoal activity of the compound against L. donovani at a dose of 1 ug/mL.; NT-Not tested
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 0 %
|
Antiprotozoal activity of the compound against L. donovani at a dose of 3 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 1.8 %
|
Antiprotozoal activity of the compound against L. donovani at a dose of 10 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 1.8 %
|
Antiprotozoal activity of the compound against L. donovani at a dose of 10 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 7.7 %
|
Antiprotozoal activity of the compound against T. b. rhodesiense at a dose of 1 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 7.7 %
|
Antiprotozoal activity of the compound against T. b. rhodesiense at a dose of 1 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 10.8 %
|
Antiprotozoal activity of the compound against T. cruzi at a dose of 1 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 10.8 %
|
Antiprotozoal activity of the compound against T. cruzi at a dose of 1 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 29 %
|
Antiprotozoal activity of the compound against T. cruzi at a dose of 3 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 29 %
|
Antiprotozoal activity of the compound against T. cruzi at a dose of 3 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 59.9 %
|
Antiprotozoal activity of the compound against T. cruzi at a dose of 10 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 59.9 %
|
Antiprotozoal activity of the compound against T. cruzi at a dose of 10 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 83.4 %
|
Antiprotozoal activity of the compound against T. b. rhodesiense at a dose of 3 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 83.4 %
|
Antiprotozoal activity of the compound against T. b. rhodesiense at a dose of 3 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 86.7 %
|
Antiprotozoal activity of the compound against T. cruzi at a dose of 30 ug/mL. Compound was toxic to host macrophages
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 86.7 %
|
Antiprotozoal activity of the compound against T. cruzi at a dose of 30 ug/mL. Compound was toxic to host macrophages
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 99.8 %
|
Antiprotozoal activity of the compound against T. b. rhodesiense at a dose of 10 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 99.8 %
|
Antiprotozoal activity of the compound against T. b. rhodesiense at a dose of 10 ug/mL.
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 99.9 %
|
Antiprotozoal activity of the compound against T. b. rhodesiense at a dose of 30 ug/mL. Compound was toxic to host macrophages
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 99.9 %
|
Antiprotozoal activity of the compound against T. b. rhodesiense at a dose of 30 ug/mL. Compound was toxic to host macrophages
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 100 %
|
Antiprotozoal activity of the compound against L. donovani at a dose of 30 ug/mL. Compound was toxic to host macrophages
|
ChEMBL.
|
14611847
|
Inhibition (functional)
|
= 100 %
|
Antiprotozoal activity of the compound against L. donovani at a dose of 30 ug/mL. Compound was toxic to host macrophages
|
ChEMBL.
|
14611847
|
Ki (binding)
|
= 0.21 nM
|
In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi
|
ChEMBL.
|
14611847
|
Ki (binding)
|
= 0.21 nM
|
In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi
|
ChEMBL.
|
14611847
|
Ki (binding)
|
= 1.87 nM
|
In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi
|
ChEMBL.
|
14611847
|
Ki (binding)
|
= 1.87 nM
|
In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi
|
ChEMBL.
|
14611847
|
Ki (binding)
|
= 1.9 nM
|
Inhibition of
|
ChEMBL.
|
18053726
|
Ki (binding)
|
= 10 nM
|
In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human
|
ChEMBL.
|
14611847
|
Ki (binding)
|
= 10 nM
|
In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human
|
ChEMBL.
|
14611847
|
Ki (binding)
|
= 15 nM
|
In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human
|
ChEMBL.
|
14611847
|
Ki (binding)
|
= 15 nM
|
Inhibition of human prolyl endopeptidase
|
ChEMBL.
|
18053726
|
Ki (binding)
|
= 15 nM
|
In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human
|
ChEMBL.
|
14611847
|
Ki (binding)
|
= 15 nM
|
Inhibition of human prolyl endopeptidase
|
ChEMBL.
|
18053726
|